Heat conduction calorimeter for massively parallel high throughput measurements with picoliter sample volumes

被引：40

作者：

Chancellor, EB

Wikswo, JP

Baudenbacher, F ^{[1
]}

Radparvar, M

Osterman, D

机构：

[1] Vanderbilt Univ, Nashville, TN 37212 USA

[2] Hypres Inc, Elmsford, NY 10523 USA

来源：

APPLIED PHYSICS LETTERS | 2004年 / 85卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1063/1.1790075

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

We have developed a bulk micromachined calorimeter with a sensitivity of 1.5 nW/Hz(1/2) and a 1 ms time constant using a thin film thermopile as the sensing element. The thermopile consists of seven titanium and bismuth thermocouples with a total Seebeck coefficient of 574 muV/K. The device is capable of measuring enthalpies in chemical or biological reactions in volumes as small as a few picoliters. The device can be fabricated and operated in a massively parallel fashion in combination with ink-jet printing technologies in air and at room temperature, making it ideally suited for biological and biochemical experiments. (C) 2004 American Institute of Physics.

引用

页码：2408 / 2410

页数：3

共 14 条

[1]

*CRC, 2004, CRC HDB PHYS CHEM

[2] THIN-FILM MICROCALORIMETER FOR HEAT-CAPACITY MEASUREMENTS FROM 1.5-K TO 800-K [J].