An asymmetric synthesis of the novel H3 agonist (+)-(3R,4R)-3-(4-imidazolyl)-4-methylpyrrolidine dihydrochloride (Sch 50971)

被引:22
作者
Aslanian, R
Lee, G
Iyer, RV
Shih, NY
Piwinski, JJ
Draper, RW
McPhail, AT
机构
[1] Schering Plough Corp, Res Inst, Dept Chem Proc Dev, Kenilworth, NJ 07033 USA
[2] Schering Plough Corp, Res Inst, Dept Chem Res, Kenilworth, NJ 07033 USA
[3] Duke Univ, Dept Chem, Paul M Gross Chem Lab, Durham, NC 27708 USA
关键词
D O I
10.1016/S0957-4166(00)00380-3
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
A short, high yielding, enantioselective synthesis of the novel H-3 agonist Sch 50971 1 is described. The key enantiodifferentiating step is the 1,4-addition of a chiral N-propionyloxazolidinone to a nitroolefin. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:3867 / 3871
页数:5
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