An asymmetric synthesis of the novel H3 agonist (+)-(3R,4R)-3-(4-imidazolyl)-4-methylpyrrolidine dihydrochloride (Sch 50971)

被引：22

作者：

Aslanian, R

Lee, G

Iyer, RV

Shih, NY

Piwinski, JJ

Draper, RW

McPhail, AT

机构：

[1] Schering Plough Corp, Res Inst, Dept Chem Proc Dev, Kenilworth, NJ 07033 USA

[2] Schering Plough Corp, Res Inst, Dept Chem Res, Kenilworth, NJ 07033 USA

[3] Duke Univ, Dept Chem, Paul M Gross Chem Lab, Durham, NC 27708 USA

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 19期

关键词：

D O I：

10.1016/S0957-4166(00)00380-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A short, high yielding, enantioselective synthesis of the novel H-3 agonist Sch 50971 1 is described. The key enantiodifferentiating step is the 1,4-addition of a chiral N-propionyloxazolidinone to a nitroolefin. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3867 / 3871

页数：5

共 15 条

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