Phenyloxazoles and phenylthiazoles as benzamide bioisosteres:: Synthesis and dopamine receptor binding profiles

被引：30

作者：

Einsiedel, J ^{[1
]}

Thomas, C ^{[1
]}

Hübner, H ^{[1
]}

Gmeiner, P ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Med Chem, Emil Fischer Ctr, D-91052 Erlangen, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(00)00405-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Conformationally restricted benzamide bioisosteres were investigated when the aminomethylpyrrolidine derivative 4o proved D3 as well as D4 binding properties which were comparable to those of the atypical neuroleptics sulpiride and clozapine, respectively. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2041 / 2044

页数：4

共 31 条

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