Cloning and characterization of mouse mSox13 cDNA

被引：21

作者：

Kido, S

Hiraoka, Y

Ogawa, M

Sakai, Y

Yoshimura, Y

Aiso, S

机构：

[1] Keio Univ, Sch Med, Dept Anat, Shinjuku Ku, Tokyo 160, Japan

[2] Tokyo Elect Power Hosp, Shinjuku Ku, Tokyo 160, Japan

[3] Keio Univ, Sch Med, Dept Obstet & Gynecol, Shinjuku Ku, Tokyo 160, Japan

来源：

GENE | 1998年 / 208卷 / 02期

关键词：

DNA binding; embryo; HMG box; leucine zipper; SRY;

D O I：

10.1016/S0378-1119(97)00667-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A novel SRY-related cDNA, mSox13, was isolated from a lambda phage library derived from mouse embryo. The cDNA encodes a protein of 595 amino acids containing the SRY-type high mobility group (HMG) box and a putative leucine zipper motif. A sequence comparison of mSox13 and other type-D SOX proteins shows that the leucine zipper and a neighboring glutamine-rich sequence stretch, which was named Q box, are well conserved among known type-D SOX proteins. The expression of mSox13 is restricted to the kidney and ovary. The electrophoretic mobility shift assay indicates that the recombinant mSox13 protein is capable of binding to the AACAAT sequence. (C) 1998 Elsevier Science B.V.

引用

收藏

页码：201 / 206

页数：6

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