The nuclear envelope and transcriptional control

被引:343
作者
Akhtar, Asifa
Gasser, Susan M.
机构
[1] European Mol Biol Lab, D-69117 Heidelberg, Germany
[2] Friedrich Miescher Inst Biomed Res, CH-4058 Basel, Switzerland
关键词
D O I
10.1038/nrg2122
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Cells have evolved sophisticated multi-protein complexes that can regulate gene activity at various steps of the transcription process. Recent advances highlight the role of nuclear positioning in the control of gene expression and have put nuclear envelope components at centre stage. On the inner face of the nuclear envelope, active genes localize to nuclear-pore structures whereas silent chromatin localizes to non-pore sites. Nuclear-pore components seem to not only recruit the RNA-processing and RNA-export machinery, but contribute a level of regulation that might enhance gene expression in a heritable manner.
引用
收藏
页码:507 / 517
页数:11
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