IFN-inducible GTPases and immunity to intracellular pathogens

被引：187

作者：

MacMicking, JD ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Boyer Ctr Mol Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA

来源：

TRENDS IN IMMUNOLOGY | 2004年 / 25卷 / 11期

关键词：

D O I：

10.1016/j.it.2004.08.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

By eliciting host antimicrobial programs in nearly all nucleated cells interferons (IFNs) help orchestrate the innate immune response of mammals to a diverse array of microbial pathogens. Recent work has highlighted the complexity of this transcriptional repertoire and the emergence of several families of IFN-inducible guanosine 5' triphosphatases (GTPases) - p47, guanylate-binding protein (GBP), Mx and very large inducible GTPases VLIG) - that subsume pathogen-specific roles. Such specificity arises from a combination of both the type and timing of inductive stimuli, target-cell population, subcellular binding partners and the infectious agent encountered. Evolution of different GTPase families to combat compartmentalized versus cytosolic pathogens reveals a hitherto unexpected level of intracellular discrimination during vertebrate host defense.

引用

页码：601 / 609

页数：9

共 89 条

[51] Immune control of tuberculosis by IFN-γ-inducible LRG-47 [J].

MacMicking, JD ;

Taylor, GA ;

McKinney, JD .

SCIENCE, 2003, 302 (5645) :654-659

[52] Upregulation of endogenous intrahepatic interferon stimulated genes during chronic hepatitis C virus infection [J].

MacQuillan, GC ;

Mamotte, C ;

Reed, WD ;

Jeffrey, GP ;

Allan, JE .

JOURNAL OF MEDICAL VIROLOGY, 2003, 70 (02) :219-227

[53] Lipopolysaccharide stimulates p38-dependent induction of antiviral genes in neutrophils independently of paracrine factors [J].

Malcolm, KC ;

Worthen, GS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (18) :15693-15701

[54]

MARTENS S, 2004, PATHOGEN HOST STANDO, pA222

[55] Nuclear factor-κB motif and interferon-α-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells [J].

Naschberger, E ;

Werner, T ;

Vicente, AB ;

Guenzi, E ;

Töpolt, K ;

Leubert, R ;

Lubeseder-Martellato, C ;

Nelson, PJ ;

Stürzl, M .

BIOCHEMICAL JOURNAL, 2004, 379 :409-420

[56] Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro [J].

Nguyen, TT ;

Hu, Y ;

Widney, DP ;

Mar, RA ;

Smith, JB .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2002, 22 (08) :899-909

[57] Genetics, cytokines and human infectious disease:: lessons from weakly pathogenic mycobacteria and salmonellae [J].

Ottenhoff, THM ;

Verreck, FAW ;

Lichtenauer-Kalígis, EGR ;

Hoeve, MA ;

Sanal, O ;

van Dissel, JT .

NATURE GENETICS, 2002, 32 (01) :97-105

[58] Immune response in stat2 knockout mice [J].

Park, C ;

Li, S ;

Cha, E ;

Schindler, C .

IMMUNITY, 2000, 13 (06) :795-804

[59] Genes expressed during the IFNγ-induced maturation of pre-B cells [J].

Patrone, L ;

Damore, MA ;

Lee, MB ;

Malone, CS ;

Wall, R .

MOLECULAR IMMUNOLOGY, 2002, 38 (08) :597-606

[60] The dynamin superfamily: Universal membrane tubulation and fission molecules? [J].

Praefcke, GJK ;

McMahon, HT .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (02) :133-147

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