Molecular mechanisms for neuronal cell death by Alzheimer's amyloid precursor protein-relevant insults

被引：43

作者：

Kawasumi, M ^{[1
]}

Hashimoto, Y ^{[1
]}

Chiba, T ^{[1
]}

Kanekura, K ^{[1
]}

Yamagishi, Y ^{[1
]}

Ishizaka, M ^{[1
]}

Tajima, H ^{[1
]}

Niikura, T ^{[1
]}

Nishimoto, I ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Pharmacol & Neurosci, Shinjuku Ku, Tokyo 1608582, Japan

来源：

NEUROSIGNALS | 2002年 / 11卷 / 05期

关键词：

Alzheimer's disease; amyloid precursor protein; amyloid-beta; neurofibrillary tangle; neuronal cell death; oxidative stress; G protein; c-jun N-terminal kinase; NADPH oxidase; humanin;

D O I：

10.1159/000067424

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To develop a therapeutic intervention for Alzheimer's disease (AD), it is necessary to clarify the mechanisms underlying the pathogenesis of AD, in which senile plaques, neurofibrillary tangles and neuronal loss in the cerebrum are the central abnormalities. A number of studies have focused on the major component of the senile plaques, which is amyloid-beta (Abeta) and its precursor protein APP, and have investigated the roles of these molecules in the onset, progression and inhibition of AD. For multiple reasons, however, their roles in AD, especially in neuronal death, remain elusive and a unified concept for their roles has not yet been established. Recently, it has been found that APP functions normally as a neuronal surface transmembrane protein. In this article, we review the molecular mechanisms of neuronal cell death by these APP-relevant insults and discuss the functions of APP in regard to intracellular signal transducers, including c-Jun N-terminal kinase. We also revise the roles of Abeta in neuronal death and survival. Copyright (C) 2002 S. Karger AG, Basel.

引用

页码：236 / 250

页数：15

共 179 条

[1]

Albers DS, 2000, J NEURAL TRANSM-SUPP, P133

[2] Multiple caspases are involved in β-amyloid-induced neuronal apoptosis [J].