Cutting Edge: Pulmonary Legionella pneumophila Is Controlled by Plasmacytoid Dendritic Cells but Not Type I IFN

被引：37

作者：

Ang, Desmond K. Y. ^{[1
]}

Oates, Clare V. L. ^{[2
]}

Schuelein, Ralf ^{[2
]}

Ly, Michelle Kel ^{[2
]}

Sansom, Fiona M. ^{[1
]}

Bourges, Dorothee ^{[1
]}

Boon, Louis ^{[4
]}

Hertzog, Paul J. ^{[3
]}

Hartland, Elizabeth L. ^{[2
]}

van Driel, Ian R. ^{[1
]}

机构：

[1] Univ Melbourne, Dept Biochem & Mol Biol, Mol Sci & Biotechnol Inst Bio21, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia

[3] Monash Inst Med Res, Cyt Innate Immun & Infect Dis, Clayton, Vic, Australia

[4] Bioceros BV, Utrecht, Netherlands

来源：

JOURNAL OF IMMUNOLOGY | 2010年 / 184卷 / 10期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

RESPIRATORY SYNCYTIAL VIRUS; COLONY-STIMULATING FACTOR; NK CELLS; INFECTION; RESPONSES; ANTIGEN; GAMMA; GENE; MICE; REPLICATION;

D O I：

10.4049/jimmunol.1000128

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasmacytoid dendritic cells (pDCs) are well known as the major cell type that secretes type I IFN in response to viral infections. Their role in combating other classes of infectious organisms, including bacteria, and their mechanisms of action are poorly understood. We have found that pDCs play a significant role in the acute response to the intracellular bacterial pathogen Legionella pneumophila. pDCs were rapidly recruited to the lungs of L. pneumophila-infected mice, and depletion of pDCs resulted in increased bacterial load. The ability of pDCs to combat infection did not require type I IFN. This study points to an unappreciated role for pDCs in combating bacterial infections and indicates a novel mechanism of action for this cell type. The Journal of Immunology, 2010, 184: 5429-5433.

引用

页码：5429 / 5433

页数：5

共 36 条

[31] Outside looking in: the inner workings of the crosspresentation pathway within dendritic cells [J].

Villadangos, Jose A. ;

Heath, William R. ;

Carbone, Francis R. .

TRENDS IN IMMUNOLOGY, 2007, 28 (02) :45-47

[32] CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen [J].

Vremec, D ;

Pooley, J ;

Hochrein, H ;

Wu, L ;

Shortman, K .

JOURNAL OF IMMUNOLOGY, 2000, 164 (06) :2978-2986

[33] Plasmacytoid dendritic cells limit viral replication, pulmonary inflammation, and airway hyperresponsiveness in respiratory syncytial virus infection [J].

Wang, Hongwei ;

Peters, Nina ;

Schwarze, Jurgen .

JOURNAL OF IMMUNOLOGY, 2006, 177 (09) :6263-6270

[34] Plasmacytoid Dendritic Cells Are Dispensable during Primary Influenza Virus Infection [J].

Wolf, Amaya I. ;

Buehler, Darya ;

Hensley, Scott E. ;

Cavanagh, Lois L. ;

Wherry, E. John ;

Kastner, Philippe ;

Chan, Susan ;

Weninger, Wolfgang .

JOURNAL OF IMMUNOLOGY, 2009, 182 (02) :871-879

[35] Naip5 affects host susceptibility to the intracellular pathogen Legionelia pneumophila [J].

Wright, EK ;

Goodart, SA ;

Growney, JD ;

Hadinoto, V ;

Endrizzi, MG ;

Long, EM ;

Sadigh, K ;

Abney, AL ;

Bernstein-Hanley, I ;

Dietrich, WF .

CURRENT BIOLOGY, 2003, 13 (01) :27-36

[36] Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells [J].

Young, Louise J. ;

Wilson, Nicholas S. ;

Schnorrer, Petra ;

Proietto, Anna ;

ten Broeke, Toine ;

Matsuki, Yohei ;

Mount, Adele M. ;

Belz, Gabrielle T. ;

O'Keeffe, Meredith ;

Ohmura-Hoshino, Mari ;

Ishido, Satoshi ;

Stoorvogel, Willem ;

Heath, William R. ;

Shortman, Ken ;

Villadangos, Jose A. .

NATURE IMMUNOLOGY, 2008, 9 (11) :1244-1252

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