Activin A and follistatin in systemic inflammation

被引:106
作者
Jones, KL [1 ]
de Kretser, DM [1 ]
Patella, S [1 ]
Phillips, DJ [1 ]
机构
[1] Monash Inst Reprod & Dev, Ctr Mol Reprod & Endocrinol, Clayton, Vic 3168, Australia
关键词
activin A; follistatin; inflammation; TNF-alpha; inteleukin-1; beta; IL-6;
D O I
10.1016/j.mce.2004.07.010
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Inflammation is a complex process regulated by a cascade of cytokines and growth factors. This review summarizes the emerging evidence implicating activin A and follistatin in the inflammatory process. Our recent studies have highlighted that activin A is released early in the process as part of the circulatory cytokine cascade during acute systemic inflammation. This release occurs concurrently with tumor necrosis factor (TNF)-alpha and prior to that of interleukin (IL)-6 and follistatin. Although, the cellular source(s) of activin A are yet to be established, circulating blood cells and the vascular endothelium are candidates for this rapid release of activin A into the circulation. The release of activin A and follistatin is also observed in the clinical setting, in particular in sepsis. Furthermore activin A is released into cerebrospinal fluid in a model of meningitis in rabbits. The role of activin A in the inflammatory response is poorly understood, however, in vitro data has highlighted that activin A can have both pro- and anti-inflammatory actions on key mediators of the inflammatory response such as TNF-alpha, IL-1beta and IL-6. Furthermore, emerging data would suggest that activin A induction is restricted to certain types of inflammation and its release is dependant upon the inflammatory setting. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:119 / 125
页数:7
相关论文
共 61 条
[11]   ACTIVIN-A ERYTHROID-DIFFERENTIATION FACTOR IS INDUCED DURING HUMAN MONOCYTE ACTIVATION [J].
ERAMAA, M ;
HURME, M ;
STENMAN, UH ;
RITVOS, O .
JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (05) :1449-1452
[12]   TGF-β in blood:: a complex problem [J].
Grainger, DJ ;
Mosedale, DE ;
Metcalfe, JC .
CYTOKINE & GROWTH FACTOR REVIEWS, 2000, 11 (1-2) :133-145
[13]   INHIBIN AND ACTIVIN REGULATE [H-3]THYMIDINE UPTAKE BY RAT THYMOCYTES AND 3T3 CELLS-INVITRO [J].
HEDGER, MP ;
DRUMMOND, AE ;
ROBERTSON, DM ;
RISBRIDGER, GP ;
DEKRETSER, DM .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1989, 61 (01) :133-138
[15]   Divergent cell-specific effects of activin-A on thymocyte proliferation stimulated by phytohemagglutinin, and interleukin 1β or interleukin 6 in vitro [J].
Hedger, MP ;
Phillips, DJ ;
de Kretser, DM .
CYTOKINE, 2000, 12 (06) :595-602
[16]  
Hubner G, 1997, LAB INVEST, V77, P311
[17]   Activin A and follistatin in acute liver failure [J].
Hughes, RD ;
Evans, LW .
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2003, 15 (02) :127-131
[18]   Activin A release into the circulation is an early event in systemic inflammation and precedes the release of follistatin [J].
Jones, KL ;
Brauman, JN ;
Groome, NP ;
de Kretser, DM ;
Phillips, DJ .
ENDOCRINOLOGY, 2000, 141 (05) :1905-1908
[19]   Characterisation of the rapid release of activin A following acute lipopolysaccharide challenge in the ewe [J].
Jones, KL ;
de Kretser, DM ;
Clarke, IJ ;
Scheerlinck, JPY ;
Phillips, DJ .
JOURNAL OF ENDOCRINOLOGY, 2004, 182 (01) :69-80
[20]   Activin A exerts both pro- and anti-inflammatory effects on human term gestational tissues [J].
Keelan, JA ;
Zhou, RL ;
Mitchell, MD .
PLACENTA, 2000, 21 (01) :38-43