Heparin-induced thrombocytopenia

被引：320

作者：

Arepally, Gowthami M. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Div Hematol, Durham, NC USA

来源：

BLOOD | 2017年 / 129卷 / 21期

基金：

美国国家卫生研究院;

关键词：

MOLECULAR-WEIGHT HEPARIN; FACTOR 4/HEPARIN ANTIBODIES; PLATELET-AGGREGATION TEST; TISSUE FACTOR EXPRESSION; UNFRACTIONATED HEPARIN; CARDIOPULMONARY BYPASS; THROMBOEMBOLIC COMPLICATIONS; WARFARIN THROMBOPROPHYLAXIS; ANTITHROMBOTIC PROPHYLAXIS; CONFORMATIONAL-CHANGES;

D O I：

10.1182/blood-2016-11-709873

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Pathogenic antibodies to PF4/heparin bind and activate cellular Fc gamma RIIA on platelets and monocytes to propagate ahypercoagulable state culminating in life-threatening thrombosis. It is now recognized that anti-PF4/and laboratory findings have also been recently harnessed for disease prevention. This review will summarize our current understanding of HIT by reviewing pathogenesis, essential clinical and laboratory features, and management.

引用

收藏

页码：2864 / 2872

页数：9

相关论文

共 131 条

[31] The HIT Expert Probability (HEP) Score: a novel pre-test probability model for heparin-induced thrombocytopenia based on broad expert opinion [J].

Cuker, A. ;

Arepally, G. ;

Crowther, M. A. ;

Rice, L. ;

Datko, F. ;

Hook, K. ;

Propert, K. J. ;

Kuter, D. J. ;

Ortel, T. L. ;

Konkle, B. A. ;

Cines, D. B. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2010, 8 (12) :2642-2650

[32] Predictive value of the 4Ts scoring system for heparin-induced thrombocytopenia: a systematic review and meta-analysis [J].

Cuker, Adam ;

Gimotty, Phyllis A. ;

Crowther, Mark A. ;

Warkentin, Theodore E. .

BLOOD, 2012, 120 (20) :4160-4167

[33] How I treat heparin-induced thrombocytopenia [J].

Cuker, Adam ;

Cines, Douglas B. .

BLOOD, 2012, 119 (10) :2209-2218

[34] C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity [J].

Dempsey, PW ;

Allison, MED ;

Akkaraju, S ;

Goodnow, CC ;

Fearon, DT .

SCIENCE, 1996, 271 (5247) :348-350

[35] HEPARIN-INDUCED THROMBOCYTOPAENIA COMPLICATED BY BILATERAL ADRENAL HEMORRHAGE [J].

ERNEST, D ;

FISHER, MM .

INTENSIVE CARE MEDICINE, 1991, 17 (04) :238-240

[36] Heparin-induced thrombocytopenia is rare in pregnancy [J].

Fausett, MB ;

Vogtlander, M ;

Lee, RM ;

Esplin, MS ;

Branch, DW ;

Rodgers, GM ;

Silver, RM .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2001, 185 (01) :148-152

[37]

FIDLAR E, 1948, J LAB CLIN MED, V33, P1410

[38] Comparison of bovine and porcine heparin in heparin antibody formation after cardiac surgery [J].

Francis, JL ;

Palmer, GJ ;

Moroose, R ;

Drexler, A .

ANNALS OF THORACIC SURGERY, 2003, 75 (01) :17-22

[39] Heparin-induced thrombocytopenia: A stoichiometry-based model to explain the differing immunogenicities of unfractionated heparin, low-molecular-weight heparin, and fondaparinux in different clinical settings [J].

Greinacher, A. ;

Alban, S. ;

Omer-Adam, M. A. ;

Weitschies, W. ;

Warkentin, T. E. .

THROMBOSIS RESEARCH, 2008, 122 (02) :211-220

[40] Heparin-induced thrombocytopenia: a prospective study on the incidence, platelet-activating capacity and clinical significance of antiplatelet factor 4/heparin antibodies of the IgG, IgM, and IgA classes [J].

Greinacher, A. ;

Juhl, D. ;

Strobel, U. ;

Wessel, A. ;

Lubenow, N. ;

Selleng, K. ;

Eichler, P. ;

Warkentin, T. E. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2007, 5 (08) :1666-1673

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