Phosphate transfer from inositol pyrophosphates InsP5PP and InsP4(PP)2:: A semi-empirical investigation

被引：32

作者：

Hand, Christine E. ^{[1
]}

Honek, John F. ^{[1
]}

机构：

[1] Univ Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

semi-empirical; PM3; SM5.2; inositol pyrophosphate; IP7; IP8; InsP(5)PP; InsP(4)(PP)(2); phosphate transfer; phosphorylation;

D O I：

10.1016/j.bmcl.2006.09.066

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel phosphate transfer process involving the non-enzymatic transfer of a phosphate group from inositol pyrophosphates to serine residues in proteins has been recently reported. Semi-empirical calculations at the PM3/SM5.2 level were undertaken to explore the effect of inositol pyrophosphate structure and overall charge on the thermodynamics of this phosphate transfer. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：183 / 188

页数：6

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