Stereoselective synthesis of β2-amino acids by Michael addition of diorgano zinc reagents to nitro acrylates

被引：51

作者：

Eilitz, U ^{[1
]}

Lessmann, F ^{[1
]}

Seidelmann, O ^{[1
]}

Wendisch, V ^{[1
]}

机构：

[1] ChiroBlock Ltd, D-06766 Wolfen, Germany

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 02期

关键词：

D O I：

10.1016/S0957-4166(02)00788-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Phosphoramidite-derived copper(I) catalysts readily facilitate the enantioselective 1,4-addition of dialkyl zinc reagents to nitro acrylates. The resulting 2-substituted 3-nitro propionic acid esters can easily be transformed to beta(2)-amino acids. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：189 / 191

页数：3

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