Molecular regulation of cognitive functions and developmental plasticity:: impact of GABAA receptors

被引：113

作者：

Moehler, Hanns

机构：

[1] Univ Zurich, Inst Pharmacol, CH-8057 Zurich, Switzerland

[2] Swiss Fed Inst Technol, ETH, Dept Chem & Appl Biosci, Zurich, Switzerland

[3] Coll Helveticum, Zurich, Switzerland

来源：

JOURNAL OF NEUROCHEMISTRY | 2007年 / 102卷 / 01期

关键词：

anxiety; memory; schizophrenia; sensory processing; sleep; AMINOBUTYRIC ACID(A) RECEPTORS; INTERNEURON DIVERSITY SERIES; ALPHA-5; SUBUNIT; BENZODIAZEPINE SITE; INVERSE AGONIST; PHARMACOLOGICAL CHARACTERIZATION; NETWORK OSCILLATIONS; PHASE PRECESSION; TONIC INHIBITION; SUBTYPES;

D O I：

10.1111/j.1471-4159.2007.04454.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By controlling spike timing and sculpting neuronal rhythms, inhibitory interneurons play a key role in regulating neuronal circuits and behavior. The pronounced diversity of GABAergic (gamma-aminobutyric acid) interneurons is paralleled by an extensive diversity of GABA(A) receptor subtypes. The region- and domain-specific location of these receptor subtypes offers the opportunity to gain functional insights into the role of defined neuronal circuits. These developments are reviewed with regard to the regulation of sleep, anxiety, memory, sensorimotor processing and post-natal developmental plasticity.

引用

页码：1 / 12

页数：12

共 140 条

[131] Low-dose alcohol actions on α4β3δ GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513 [J].