Tetrahydronaphthalenic derivatives as new agonist and antagonist ligands for melatonin receptors

被引：33

作者：

Fourmaintraux, E

Depreux, P

Lesieur, D

Guardiola-Lemaitre, B

Bennejean, C

Delagrange, P

Howell, HE

机构：

[1] Inst Chim Pharmaceut, F-59006 Lille, France

[2] ADIR & Cie, F-92415 Courbevoie, France

[3] Rowett Res Inst, Aberdeen, Scotland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1998年 / 6卷 / 01期

关键词：

D O I：

10.1016/S0968-0896(97)00175-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Tetrahydronaphthalenic ligands were synthesized and evaluated as melatonin receptor ligands. Biological studies show that the aromaticity of the ring bearing the side chain is not essential for affinity and activity and that replacement of the methoxy group with the bioisostere ethyl which does not offer the possibility of H-bonding, leads to antagonist or forskoline potentiating properties. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：9 / 13

页数：5

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