Synthesis of N-diisopropyl phosphoryl benzyltetrahydroisoquinoline, a new class of mitochondrial complexes I and III inhibitors

被引：4

作者：

Andreu, I

Cabedo, N

Tormo, JR

Bermejo, A

Mello, R

Cortes, D ^{[1
]}

机构：

[1] Univ Valencia, Dept Farmacol Farmacognosia & Farmacodinamia, E-46100 Valencia, Spain

[2] Univ Valencia, Serv Cent Soporte Invest Expt, E-46100 Valencia, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(00)00262-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The synthesis of N-(O,O-diisopropyl phosphoryl)-benzyltetrahydroisoquinoline (3) has been achieved in a 'one pot' procedure From imine (2) and diisopropyl-phosphorochloridate (1) generated in situ (POCl3 + iPrOH). Compound 3 is the first benzyltetrahydroisoquinoline derivative found to be a potent inhibitor of mitochondrial complexes I and III, and therefore it opens a new perspective with this series of compounds as they can be considered as new class of antitumor agents. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：1491 / 1494

页数：4

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