Origin, fate and dynamics of macrophages at central nervous system interfaces

被引：898

作者：

Goldmann, Tobias ^{[1
]}

Wieghofer, Peter ^{[1
,2
]}

Jordao, Marta Joana Costa ^{[1
,2
]}

Prutek, Fabiola ^{[1
]}

Hagemeyer, Nora ^{[1
]}

Frenzel, Kathrin ^{[1
,2
]}

Amann, Lukas ^{[1
,2
]}

Staszewski, Ori ^{[1
]}

Kierdorf, Katrin ^{[1
]}

Krueger, Martin ^{[3
]}

Locatelli, Giuseppe ^{[4
]}

Hochgerner, Hannah ^{[5
]}

Zeiser, Robert ^{[6
,7
]}

Epelman, Slava ^{[8
]}

Geissmann, Frederic ^{[9
]}

Priller, Josef ^{[10
,11
,12
,13
]}

Rossi, Fabio M. V. ^{[14
]}

Bechmann, Ingo ^{[3
]}

Kerschensteiner, Martin ^{[4
,15
]}

Linnarsson, Sten ^{[5
]}

Jung, Steffen ^{[16
]}

Prinz, Marco ^{[1
,7
]}

机构：

[1] Univ Freiburg, Med Ctr, Inst Neuropathol, Freiburg, Germany

[2] Univ Freiburg, Fac Biol, Hugstetter Str 55, D-79106 Freiburg, Germany

[3] Univ Leipzig, Inst Anat, D-04109 Leipzig, Germany

[4] Univ Munich, Inst Klin Neuroimmunol, Munich, Germany

[5] Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden

[6] Univ Freiburg, Med Ctr, Dept Hematol & Oncol, Freiburg, Germany

[7] Univ Freiburg, BIOSS Ctr Biol Signaling Studies, Hugstetter Str 55, D-79106 Freiburg, Germany

[8] Univ Hlth Network Toronto, Peter Munk Cardiac Ctr, Toronto, ON, Canada

[9] Kings Coll London, Ctr Mol & Cellular Biol Inflammat, London, England

[10] Charite, Dept Neuropsychiat, D-13353 Berlin, Germany

[11] Charite, Lab Mol Psychiat, D-13353 Berlin, Germany

[12] DZNE, Cluster Excellence NeuroCure, Berlin, Germany

[13] BIH, Berlin, Germany

[14] Univ British Columbia, Fac Med, Biomed Res Ctr, Vancouver, BC V5Z 1M9, Canada

[15] Munich Cluster Syst Neurol SyNergy, Munich, Germany

[16] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

来源：

NATURE IMMUNOLOGY | 2016年 / 17卷 / 07期

关键词：

MYELOID CELLS; CHOROID-PLEXUS; CARDIAC MACROPHAGES; MICROGLIAL CELLS; SELF-RENEWAL; STEADY-STATE; CNS; MONOCYTES; RESIDENT; REVEALS;

D O I：

10.1038/ni.3423

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Perivascular, subdural meningeal and choroid plexus macrophages are non-parenchymal macrophages that mediate immune responses at brain boundaries. Although the origin of parenchymal microglia has recently been elucidated, much less is known about the precursors, the underlying transcriptional program and the dynamics of the other macrophages in the central nervous system (CNS). It was assumed that they have a high turnover from blood-borne monocytes. However, using parabiosis and fate-mapping approaches in mice, we found that CNS macrophages arose from hematopoietic precursors during embryonic development and established stable populations, with the notable exception of choroid plexus macrophages, which had dual origins and a shorter life span. The generation of CNS macrophages relied on the transcription factor PU.1, whereas the MYB, BATF3 and NR4A1 transcription factors were not required.

引用

页码：797 / +

页数：11

共 52 条

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Upregulation of flt3 expression within the bone marrow Lin-Sca1+c-kit+ stem cell compartment is accompanied by loss of self-renewal capacity [J].