Systems biology experimental design - Considerations for building predictive gene regulatory network models for prokaryotic systems

被引：14

作者：

Facciotti, MT ^{[1
]}

Bonneau, R ^{[1
]}

Hood, L ^{[1
]}

Baliga, NS ^{[1
]}

机构：

[1] Inst Syst Biol, Seattle, WA 98103 USA

来源：

CURRENT GENOMICS | 2004年 / 5卷 / 07期

关键词：

systems biology; experimental design; prokaryotic; quantitative;

D O I：

10.2174/1389202043348850

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The goal of systems biology is to describe and quantitatively model complete biological systems. It is a reasonable goal to begin by developing quantitative models that accurately recapitulate many aspects of gene regulatory networks for some simple organisms. We consider here the advantages of using prokaryotic organisms as model systems in the initial development of such quantitative models. In addition, we discuss some of the benefits of studying stress responses in these organisms and illustrate some of the biological and theoretical complexities facing the analyses of dynamic biological systems.

引用

收藏

页码：527 / 544

页数：18

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