Synthesis of uracil polyoxin C from uridine

被引：36

作者：

Evina, CM ^{[1
]}

Guillerm, G ^{[1
]}

机构：

[1] UFR SCI,LAB CHIM BIOORGAN ASSOCIE CNRS,F-51687 REIMS 2,FRANCE

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 02期

关键词：

D O I：

10.1016/0040-4039(95)02116-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved procedure is reported for the asymmetric synthesis of uracil polyoxin C (UPOC) from 2',3'-O-isopropylideneuridine-5'-aldehyde. The methodology described here is based on the highly diastereocontrolled formation of 1-(beta-D-allofuranosyl)uracil and its facile conversion into the corresponding 2,5'-O-cyclouridine derivative, a key step for the stereocontrolled formation of the terminal alpha-amino acid of UPOC.

引用

页码：163 / 166

页数：4

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