6-hydroxyflavonoids as α-glucosidase inhibitors from marjoram (Origanum majorana) leaves

被引：75

作者：

Kawabata, J ^{[1
]}

Mizuhata, K ^{[1
]}

Sato, E ^{[1
]}

Nishioka, T ^{[1
]}

Aoyama, Y ^{[1
]}

Kasai, T ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Agr, Div Appl Biosci, Lab Food Biochem,Kita Ku, Sapporo, Hokkaido 0608589, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2003年 / 67卷 / 02期

关键词：

6-hydroxyflavone; Origanum majorana; marjoram; alpha-glucosidase inhibitor;

D O I：

10.1271/bbb.67.445

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A methanol extract of marjoram leaves strongly inhibited rat intestinal alpha-glucosidase. Five 6-hydroxyflavonoids, 6-hydroxyapigenin (scutellarein; IC50 for sucrose hydrolysis by rat intestinal alpha-glucosidase, 12 muM), 6-hydroxyapigenin-7-O-beta-D-glucopyranoside (>500 muM), 6-hydroxyluteolin-7-O-beta-D-glucopyranoside (300 muM), 6-hydroxyapigenin-7-O-(6-O-feruloyl)-beta-D-glucopyranoside (>500 muM), and 6-hydroxyluteolin-7-O-(6-O-feruloyl)-beta-D-glucopyranoside (>500 muM), were isolated as active principles and related compounds. The two feruloylglucosides are novel compounds.

引用

页码：445 / 447

页数：3

共 12 条

[1]

COMPARATIVE BIOCHEMISTRY OF FLAVONOIDS .6. FLAVONOID PATTERNS IN BIGNONIACEAE AND GESNERIACEAE [J].