B-cell commitment: deciding on the players

被引：54

作者：

Hardy, RR ^{[1
]}

机构：

[1] Fox Chase Canc Ctr, Inst Canc Res, Philadelphia, PA 19111 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(03)00012-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Considerable progress has been made over the past few years in determining the key molecular players that regulate the commitment and development of early B-lineage cells in mouse bone marrow (transcription factors, cytokines and their receptors). However, confusion remains as to the precise stages, surface phenotypes and lineage restrictions that are observed early in B-cell development. Increasingly powerful flow cytometry analysis of genetically altered animals (knockouts and transgenics) combined with sensitive functional assays may provide an answer, a 'scorecard' for the cell stages.

引用

页码：158 / 165

页数：8

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