Harnessing HIV for therapy, basic research and biotechnology

被引：76

作者：

Wiznerowicz, M

Trono, D ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Sch Life Sci, Natl Ctr Competence Res, Lausanne, Switzerland

[2] Univ Geneva, Sch Med, Dept Microbiol & Mol Med, CH-1211 Geneva, Switzerland

来源：

TRENDS IN BIOTECHNOLOGY | 2005年 / 23卷 / 01期

关键词：

D O I：

10.1016/j.tibtech.2004.11.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

First described about a decade ago, lentiviral vectors ('lentivectors') have emerged as potent and versatile tools of gene transfer for basic and applied research and offer exciting perspectives for the field of gene therapy. In the clinic, HIV-based vectors are showing particular promise for delivering therapeutic genes to hematopoietic stem cells (HSCs) and terminally differentiated targets in the central nervous system (CNS). Their flexible design facilitates the accommodation of sophisticated elements of control for the precise tuning of transgene expression. The delivery of small interfering RNAs (siRNAs) and genomic or cDNA libraries and the creation of transgenic animals are the most recent and exciting applications of HIV-based vectors that will help to tackle fundamental issues across wide areas of biology.

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页码：42 / 47

页数：6

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