In Vitro Fungicidal Activities of Echinocandins against Candida metapsilosis, C. orthopsilosis, and C. parapsilosis Evaluated by Time-Kill Studies

被引：54

作者：

Canton, Emilia ^{[1
]}

Espinel-Ingroff, Ana ^{[2
]}

Peman, Javier ^{[3
]}

del Castillo, Lucas ^{[4
]}

机构：

[1] Hosp Univ La Fe, Ctr Invest, Unidad Microbiol Expt, Valencia 46009, Spain

[2] VCU Med Ctr, Richmond, VA USA

[3] Hosp Univ La Fe, Microbiol Serv, Valencia 46009, Spain

[4] Univ Valencia, Fac Farm, Dept Microbiol & Ecol, E-46010 Valencia, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 05期

关键词：

ANTIFUNGAL SUSCEPTIBILITY; AMPHOTERICIN-B; CASPOFUNGIN; MICAFUNGIN; PREVALENCE; KINETICS;

D O I：

10.1128/AAC.01538-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Anidulafungin, micafungin, and caspofungin in vitro activities against Candida metapsilosis, C. orthopsilosis, and C. parapsilosis were evaluated by MICs and time-kill methods. All echinocandins showed lower MICs (mean MICs, 0.05 to 0.71 mg/liter) and the highest killing rates (-0.06 to -0.05 CFU/ml/h) for C. metapsilosis and C. orthopsilosis rather than for C. parapsilosis (mean MICs, 0.59 to 1.68 mg/liter). Micafungin and anidulafungin killing rates were greater than those determined for caspofungin. None of the echinocandins had fungicidal activity against C. parapsilosis.

引用

页码：2194 / 2197

页数：4

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