Application of a polymeric solid phase extraction for the analysis of sulfonamides in milk by LC/MS

被引：17

作者：

Kim, DH ^{[1
]}

Choi, JO

Kim, J

Lee, DW

机构：

[1] Korea Res Inst Stand & Sci, Div Chem Metrol & Mat Evaluat, Organ Anal Lab, Taejon 305600, South Korea

[2] Yonsei Univ, Dept Chem, Seoul 120749, South Korea

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2003年 / 26卷 / 07期

关键词：

sulfonamides; milk; SPE; LC/MS; APCI;

D O I：

10.1081/JLC-120020100

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple clean up method for sulfonamides in milk, using a solvent extraction and unprecedented solid phase extraction (SPE) was studied. The effects of solid phase's type, solvent's type, and sample's pH on the extraction of sulfonamids were compared. Sample extracts were simply cleaned up and enriched by SPE on LiChrolut EN (ethylvinylbenzene-divinylbenzene-copolymer). Liquid chromatography/atmospheric pressure chemical ionization-mass spectrometry (LC/APCI-MS) was used for the determination of sulfonamides. Milk samples, spiked with 8.2 ng/mL of sulfamethazine (SMZ), were assayed with a relative standard deviation (RSD) of 2.8% using isotope labeled internal standards.

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收藏

页码：1149 / 1159

页数：11

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