Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1

被引：17

作者：

Bremner, John B. ^{[1
]}

Keller, Paul A. ^{[1
]}

Pyne, Stephen G. ^{[1
]}

Boyle, Timothy P. ^{[1
]}

Brkic, Zinka ^{[1
]}

David, Dorothy M. ^{[1
]}

Robertson, Mark ^{[1
]}

Somphol, Kittiya ^{[1
]}

Baylis, Dean ^{[2
]}

Coates, Jonathan A. ^{[2
]}

Deadman, John ^{[2
]}

Jeevarajah, Darshini ^{[2
]}

Rhodes, David I. ^{[2
]}

机构：

[1] Univ Wollongong, Sch Chem, Wollongong, NSW 2522, Australia

[2] Avexa Ltd, Richmond, Vic 3121, Australia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 07期

基金：

英国医学研究理事会;

关键词：

Tripeptoids; Cationic; Antibacterial; Binaphthyl; ANTIMICROBIAL PEPTIDOMIMETICS; LIPOGLYCOPEPTIDE; RESISTANCE; VANCOMYCIN; MEMBRANE; PEPTIDES; PEPTOIDS;

D O I：

10.1016/j.bmc.2010.02.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

An efficient synthesis of 29 new binaphthyl-based neutral, and mono- and di-cationic, peptoids is described. Some of these compounds had antibacterial activities with MIC values of 1.9-3.9 mu g/mL against Staphylococcus aureus. One peptoid had a MIC value of 6 mu g/mL against a methicillin-resistant strain of S. aureus ( MRSA) and a MIC value of 2 mu g/mL against vancomycin-resistant strains of enterococci (VRE). (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2611 / 2620

页数：10

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