Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials

被引：14

作者：

Boyle, Timothy P. ^{[1
]}

Bremner, John B. ^{[1
]}

Coates, Jonathan A. ^{[2
]}

Deadman, John ^{[2
]}

Keller, Paul A. ^{[1
]}

Pyne, Stephen G. ^{[1
]}

Somphol, Kittiya ^{[1
]}

机构：

[1] Univ Wollongong, Sch Chem, Wollongong, NSW 2522, Australia

[2] Avexa Ltd, Richmond, Vic 3121, Australia

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 03期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

Anthracenyl phenylalanines; Phenanthrenyl phenylalanines; Cationic peptoids; Antibacterials; EFFICIENT SYNTHESIS; VANCOMYCIN; RESISTANCE; PEPTOIDS;

D O I：

10.1016/j.ejmech.2008.07.001

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

An efficient synthesis of two new N-acetyl-4'-arylphenylalanines is described together with their incorporation into a number of cationic peptoid antibacterial agents, one of which had an MIC of 7.8 mu g/mL against Staphylococcus aureus. Crown Copyright (C) 2008 Published by Elsevier Masson SAS. All rights reserved.

引用

页码：1001 / 1009

页数：9

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