Application of the Suzuki-Miyaura cross-coupling to increase antimicrobial potency generates promising novel antibacterials

被引：37

作者：

Haug, Bengt Erik

Stensen, Wenche

Svendsen, John S.

机构：

[1] Univ Tromso, Dept Chem, N-9037 Tromso, Norway

[2] Lytix Biopharma AS, N-9294 Tromso, Norway

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 08期

关键词：

cationic antimicrobial peptide; Suzuki-Miyaura coupling; antibacterial drugs;

D O I：

10.1016/j.bmcl.2006.12.049

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Antimicrobial peptides have been recognized as a novel class of antibiotics, and several candidates are currently in clinical trials. In this work, a tripeptide derivative containing 4-iodo phenylalanine has been derivatized through the Suzuki-Miyaura cross-coupling. This has enabled the rapid and efficient synthesis of an array of tripeptide derivatives encompassing novel biaryl moieties. The peptide derivatives show high activity against Gram-positive bacteria. (c) 2007 Elsevier Ltd. All rights reserved.

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收藏

页码：2361 / 2364

页数：4

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