Room-Temperature Direct Arylation of Polyfluorinated Arenes under Biphasic Conditions

被引：173

作者：

Rene, Olivier ^{[1
]}

Fagnou, Keith ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 09期

基金：

加拿大自然科学与工程研究理事会;

关键词：

CATALYZED DIRECT ARYLATION; C-H BOND; INTERMOLECULAR DIRECT ARYLATION; ACTIVATION; FUNCTIONALIZATION; ALKENYLATION; ACID;

D O I：

10.1021/ol1006136

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New biphasic conditions for the palladium-catalyzed direct arylation of electron-poor fluorinated arenes have been developed. Taking advantage of biphasic chemistry, the use of an immiscible mixture of water and an organic solvent allows complete solubilization of all components of the system, enabling the reaction to proceed at room temperature in yields up to 99%.

引用

页码：2116 / 2119

页数：4

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