Solid-phase combinatorial synthesis of 5-arylalkylidene rhodanine

被引：46

作者：

Lee, CL ^{[1
]}

Sim, MM ^{[1
]}

机构：

[1] Inst Mol & Cell Biol, Singapore 117609, Singapore

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 30期

关键词：

solid-phase synthesis; rhodanine; aldehydes; ketones; condensation;

D O I：

10.1016/S0040-4039(00)00866-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rhodanine-3-acetic acid was loaded on Wang resin or Rink amide resin. Alternatively, the thiocarbonyl-diimidazole-activated Wang amino acid resin or 2-chlorotrityl resin was reacted with methyl thioglycolate to yield the rhodanine moieties. It was then condensed at the C-5 active methylene with either aromatic aldehydes or aromatic ketones. 5-Arylalkylidene rhodanine was obtained upon resin cleavage. (C) 2000 Elsevier Science Ltd. All rights reserved.

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收藏

页码：5729 / 5732

页数：4

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