Novel indole containing thiazolidinedione derivatives as potent euglycemic and hypolipidaemic agents

被引：39

作者：

Lohray, BB

Bhushan, V

Rao, PB

Madhavan, GR

Murali, N

Rao, KN

Reddy, KA

Rajesh, BM

Reddy, PG

Chakrabarti, R

Rajagopalan, R

机构：

[1] Drug Discovery Group, Dr. Reddy's Research Foundation, Miyapur, Hyderabad 500 138, Bollaram Road

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(97)00118-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several thiazolidinediones having indol as heterocyclic moiety have been synthesized and evaluated for euglycemic properties. A few of them have been found to be superior to troglitazone. (C) 1997 Elsevier Science Ltd.

引用

页码：785 / 788

页数：4

共 29 条

[1] Non thiazolidinedione antihyperglycaemic agents .1. alpha-heteroatom substituted beta-phenylpropanoic acids [J].

Buckle, DR ;

Cantello, BCC ;

Cawthorne, MA ;

Coyle, PJ ;

Dean, DK ;

Faller, A ;

Haigh, D ;

Hindley, RM ;

Jefcott, LJ ;

Lister, CA ;

Pinto, IL ;

Rami, HK ;

Smith, DG ;

Smith, SA .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (17) :2121-2126

[2] Non thiazolidinedione antihyperglycaemic agents .2. alpha-carbon substituted beta-phenylpropanoic acids [J].

Buckle, DR ;

Cantello, BCC ;

Cawthorne, MA ;

Coyle, PJ ;

Dean, DK ;

Faller, A ;

Haigh, D ;

Hindley, RM ;

Jefcott, LJ ;

Lister, CA ;

Pinto, IL ;

Rami, HK ;

Smith, DG ;

Smith, SA .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (17) :2127-2130

[3] [[OMEGA-(HETEROCYCLYLAMINO)ALKOXY]BENZYL]-2,4-THIAZOLIDINEDIONES AS POTENT ANTIHYPERGLYCEMIC AGENTS [J].

CANTELLO, BCC ;

CAWTHORNE, MA ;

COTTAM, GP ;

DUFF, PT ;

HAIGH, D ;

KINDLEY, RM ;

LISTER, CA ;

SMITH, SA ;

THURLBY, PL .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (23) :3977-3985

[4] CIGLITAZONE, A NEW HYPOGLYCEMIC AGENT .1. STUDIES IN OB/OB AND DB/DB MICE, DIABETIC CHINESE HAMSTERS, AND NORMAL AND STREPTOZOTOCIN-DIABETIC RATS [J].

CHANG, AY ;

WYSE, BM ;

GILCHRIST, BJ ;

PETERSON, T ;

DIANI, AR .

DIABETES, 1983, 32 (09) :830-838

[5] SUBSTITUTED DIHYDROBENZOPYRAN AND DIHYDROBENZOFURAN THIAZOLIDINE-2,4-DIONES AS HYPOGLYCEMIC AGENTS [J].

CLARK, DA ;

GOLDSTEIN, SW ;

VOLKMANN, RA ;

EGGLER, JF ;

HOLLAND, GF ;

HULIN, B ;

STEVENSON, RW ;

KREUTTER, DK ;

GIBBS, EM ;

KRUPP, MN ;

MERRIGAN, P ;

KELBAUGH, PL ;

ANDREWS, EG ;

TICKNER, DL ;

SULESKE, RT ;

LAMPHERE, CH ;

RAJECKAS, FJ ;

KAPPELER, WH ;

MCDERMOTT, RE ;

HUTSON, NJ ;

JOHNSON, MR .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) :319-325

[6]

COLCA JR, 1992, ANNU REP MED CHEM, V27, P219

[7]

DELDAR A, 1993, DIABETES, V42, pA57

[8] BENZYLOXAZOLIDINE-2,4-DIONES AS POTENT HYPOGLYCEMIC AGENTS [J].

DOW, RL ;

BECHLE, BM ;

CHOU, TT ;

CLARK, DA ;

HULIN, B ;

STEVENSON, RW .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (05) :1538-1544

[9] ANTIHYPERGLYCEMIC ACTIVITY OF NOVEL SUBSTITUTED 3H-1,2,3,5-OXATHIADIAZOLE 2-OXIDES [J].

ELLINGBOE, JW ;

ALESSI, TR ;

DOLAK, TM ;

NGUYEN, TT ;

TOMER, JD ;

GUZZO, F ;

BAGLI, JF ;

MCCALEB, ML .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (07) :1176-1183

[10] ANTIHYPERGLYCEMIC ACTIVITY OF NOVEL NAPHTHALENYL 3H-1,2,3,5-OXATHIADIAZOLE 2-OXIDES [J].

ELLINGBOE, JW ;

LOMBARDO, LJ ;

ALESSI, TR ;

NGUYEN, TT ;

GUZZO, F ;

GUINOSSO, CJ ;

BULLINGTON, J ;

BROWNE, ENC ;

BAGLI, JF ;

WRENN, J ;

STEINER, K ;

MCCALEB, ML .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (17) :2485-2493

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