Increased microparticle tissue factor activity in cancer patients with Venous Thromboembolism

被引：171

作者：

Manly, David A. ^{[1
]}

Wang, Jianguo ^{[1
]}

Glover, Sam L. ^{[1
]}

Kasthuri, Raj ^{[1
]}

Liebman, Howard A. ^{[2
]}

Key, Nigel S. ^{[1
]}

Mackman, Nigel ^{[1
]}

机构：

[1] Univ N Carolina, Dept Med, Div Hematol Oncol, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Univ So Calif, Keck Sch Med, Dept Med,Norris Comprehens Canc Ctr, Jane Anne Nohl Div Hematol, Los Angeles, CA 90033 USA

来源：

THROMBOSIS RESEARCH | 2010年 / 125卷 / 06期

关键词：

Tissue factor; Microparticles; Venous thrombosis; Cancer; FACTOR-POSITIVE MICROPARTICLES; PROCOAGULANT MICROPARTICLES; VIENNA CANCER; COAGULATION; ACTIVATION;

D O I：

10.1016/j.thromres.2009.09.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cancer patients exhibit a high rate of thromboembolism (VTE). In this study, we analyzed levels of microparticle (MP) tissue factor (TF) activity in cancer patients with or without VTE. Blood was collected from cancer patients within 24 h of objectively diagnosed VTE (n=53) and from cancer patients without VTE (n=13). MPs were isolated from platelet poor plasma by centrifugation at 20,000g for 15 min. MP TF activity was measured using a two-stage chromogenic assay. Cancer patients with VTE had a significantly higher mean MP TF activity compared with cancer patients without VTE (1.7 +/- 3.8 pg/mL vs 0.6 +/- 0.4 pg/mL, p<0.05). Further prospective studies are required to determine if levels of MP TF activity may be a useful biomarker to identify patients at increased risk for VTE. (C) 2009 Elsevier Ltd. All rights reserved.

引用

收藏

页码：511 / 512

页数：2

相关论文

共 19 条

[1] Induction of microparticle- and cell-associated intravascular tissue factor in human endotoxemia [J].

Aras, O ;

Shet, A ;

Bach, RR ;

Hysjulien, JL ;

Slungaard, A ;

Hebbel, RP ;

Escolar, G ;

Jilma, B ;

Key, NS .

BLOOD, 2004, 103 (12) :4545-4553

[2] High plasma levels of soluble P-selectin are predictive of venous thromboembolism in cancer patients: results from the Vienna Cancer and Thrombosis Study (CATS) [J].

Ay, Cihan ;

Simanek, Ralph ;

Vormittag, Rainer ;

Dunkler, Daniela ;

Alguel, Guelay ;

Koder, Silvia ;

Kornek, Gabriela ;

Marosi, Christine ;

Wagner, Oswald ;

Zielinski, Christoph ;

Pabinger, Ingrid .

BLOOD, 2008, 112 (07) :2703-2708

[3] D-Dimer and Prothrombin Fragment 1+2 Predict Venous Thromboembolism in Patients With Cancer: Results From the Vienna Cancer and Thrombosis Study [J].

Ay, Cihan ;

Vormittag, Rainer ;

Dunkler, Daniela ;

Simanek, Ralph ;

Chiriac, Alexandru-Laurentiu ;

Drach, Johannes ;

Quehenberger, Peter ;

Wagner, Oswald ;

Zielinski, Christoph ;

Pabinger, Ingrid .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (25) :4124-4129

[4] Circulating procoagulant microparticles in patients with venous thromboembolism [J].

Ay, Cihan ;

Freyssinet, Jean-Marie ;

Sailer, Thomas ;

Vormittag, Rainer ;

Pabinger, Ingrid .

THROMBOSIS RESEARCH, 2009, 123 (05) :724-726

[5] Inflammation and Liver Cancer New Molecular Links [J].

Berasain, C. ;

Castillo, J. ;

Perugorria, M. J. ;

Latasa, M. U. ;

Prieto, J. ;

Avila, M. A. .

STEROID ENZYMES AND CANCER, 2009, 1155 :206-221

[6] Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein [J].

Bogdanov, VY ;

Balasubramanian, V ;

Hathcock, J ;

Vele, O ;

Lieb, M ;

Nemerson, Y .

NATURE MEDICINE, 2003, 9 (04) :458-462

[7] Elevation of endothelial microparticles, platelets, and leukocyte activation in patients with venous thromboembolism [J].

Chirinos, JA ;

Heresi, GA ;

Velasquez, H ;

Jy, W ;

Jimenez, JJ ;

Ahn, E ;

Horstman, LL ;

Soriano, AO ;

Zambrano, JP ;

Ahn, YS .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2005, 45 (09) :1467-1471

[8]

Cosmi B, 2005, HAEMATOLOGICA, V90, P713

[9] Tissue factor-positive microparticles: Cellular origin and association with coagulation activation in patients with colorectal cancer [J].

Hron, Gregor ;

Kollars, Marietta ;

Weber, Heinz ;

Sagaster, Verena ;

Quehenberger, Peter ;

Eichinger, Sabine ;

Kyrle, Paul A. ;

Weltermann, Ansgar .

THROMBOSIS AND HAEMOSTASIS, 2007, 97 (01) :119-123

[10] Plasma tissue factor may be predictive of venous thromboembolism in pancreatic cancer [J].

Khorana, A. A. ;

Francis, C. W. ;

Menzies, K. E. ;

Wang, J. -G. ;

Hyrien, O. ;

Hathcock, J. ;

Mackman, N. ;

Taubman, M. B. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2008, 6 (11) :1983-1985