Oral fluid as a diagnostic tool

被引：121

作者：

Choo, RE ^{[1
]}

Huestis, MA ^{[1
]}

机构：

[1] NIDA, Chem & Drug Metab Sect, Intramural Res Program, NIH, Baltimore, MD 21224 USA

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2004年 / 42卷 / 11期

关键词：

illicit drugs; oral fluid; saliva; therapeutic drug monitoring;

D O I：

10.1515/CCLM.2004.248

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Technological advances over the past decades have enabled oral fluid to expand its usefulness in the diagnosis of disease, prediction of disease progression, monitoring of therapeutic drug levels and detection of illicit drugs. The easy non-invasive nature of collection and the relationship between oral fluid and plasma levels make oral fluid a valuable clinical tool. This review describes advances over the past 5 years in the area of oral fluid as a diagnostic tool, its use in therapeutic and illicit drug monitoring, including proposed guidelines for cut-off values, and methods of collection.

引用

页码：1273 / 1287

页数：15

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