Effects of MHC class I on HIV/SIV disease in primates

被引:24
作者
Carrington, M [1 ]
Bontrop, RE
机构
[1] NCI, SAIC Frederick, Basic Res Program, Frederick, MD 21702 USA
[2] Biomed Primate Res Ctr, NL-2280 GH Rijswijk, Netherlands
关键词
HIV-1; SIV; MHC; HLA; primates;
D O I
10.1097/00002030-200216004-00015
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Data indicate that resistance to HIV-1 disease involves an array of contrasting HLA genotypic effects that are subtle, but significant, particularly when these genetic effects are considered as a whole. Numerous reports attributing a role for HLA genotype in AIDS outcomes have been reported, and a few of these have been affirmed in multiple studies. Functional studies of immune cell recognition have provided clues to the underlying mechanisms behind some of the strongest HLA associations, suggesting the means by which relative resistance or susceptibility to the virus may occur. SIV infection in non-human primates has served as an invaluable model for understanding AIDS pathogenesis (in rhesus monkeys) and viral resistance (in chimpanzee). The effect of rhesus MHC class I molecules on the evolution of SIV has been convincingly described [19], and a recent study in humans has suggested that selection pressure conferred by HLA molecules is responsible for specific genetic variation in HIV-1 [114]. HIV-1 may eventually have conspicuous evolutionary effects on HLA and other AIDS restriction genes, a prolonged process that could have occurred in chimpanzee [92]. To prevent such an outcome, it will be necessary to approach the disease from many perspectives, and apply comprehensively the knowledge gained to the successful control of the virus.
引用
收藏
页码:S105 / S114
页数:10
相关论文
共 115 条
[81]  
Martin MP, 2002, NAT GENET, V31, P429, DOI 10.1038/ng934
[82]   Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques [J].
Matano, T ;
Shibata, R ;
Siemon, C ;
Connors, M ;
Lane, HC ;
Martin, MA .
JOURNAL OF VIROLOGY, 1998, 72 (01) :164-169
[83]   A UNIQUELY HIGH-LEVEL OF RECOMBINATION AT THE HLA-B LOCUS [J].
MCADAM, SN ;
BOYSON, JE ;
LIU, XM ;
GARBER, TL ;
HUGHES, AL ;
BONTROP, RE ;
WATKINS, DI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (13) :5893-5897
[84]  
MCADAM SN, 1995, J IMMUNOL, V154, P6421
[85]   Identification of five different Patr class I molecules that bind HLA supertype peptides and definition of their peptide binding motifs [J].
McKinney, DM ;
Erickson, AL ;
Walker, CM ;
Thimme, R ;
Chisari, FV ;
Sidney, J ;
Sette, A .
JOURNAL OF IMMUNOLOGY, 2000, 165 (08) :4414-4422
[86]   HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors [J].
Migueles, SA ;
Sabbaghian, MS ;
Shupert, WL ;
Bettinotti, MP ;
Marincola, FM ;
Martino, L ;
Hallahan, CW ;
Selig, SM ;
Schwartz, D ;
Sullivan, J ;
Connors, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (06) :2709-2714
[87]   Molecular and immunological significance of chimpanzee major histocompatibility complex haplotypes for hepatitis C virus immune response and vaccination studies [J].
Mizukoshi, E ;
Nascimbeni, M ;
Blaustein, JB ;
Mihalik, K ;
Rice, CM ;
Liang, TJ ;
Feinstone, SM ;
Rehermann, B .
JOURNAL OF VIROLOGY, 2002, 76 (12) :6093-6103
[88]   Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level [J].
Moore, CB ;
John, M ;
James, IR ;
Christiansen, FT ;
Witt, CS ;
Mallal, SA .
SCIENCE, 2002, 296 (5572) :1439-1443
[89]   Characterization of the peptide-binding specificity of Mamu-B*17 and identification of Mamu-B*17-restricted epitopes derived from simian immunodeficiency virus proteins [J].
Mothé, BR ;
Sidney, J ;
Dzuris, JL ;
Liebl, ME ;
Fuenger, S ;
Watkins, DI ;
Sette, A .
JOURNAL OF IMMUNOLOGY, 2002, 169 (01) :210-219
[90]   GENETIC AND SEROLOGICAL HETEROGENEITY OF THE SUPERTYPIC HLA-B LOCUS SPECIFICITIES BW4 AND BW6 [J].
MULLER, CA ;
ENGLERBLUM, G ;
GEKELER, V ;
STEIERT, I ;
WEISS, E ;
SCHMIDT, H .
IMMUNOGENETICS, 1989, 30 (03) :200-207