Antimycobacterial pimarane diterpenes from the fungus Diaporthe sp.

被引：80

作者：

Dettrakul, S

Kittakoop, P

Isaka, M

Nopichai, S

Suyarnsestakorn, C

Tanticharoen, M

Thebtaranonth, Y

机构：

[1] NSTDA, BIOTEC, Natl Ctr Genet Engn & Biotechnol, Klongluang 12120, Pathumthani, Thailand

[2] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(03)00111-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Two new pimarane diterpenes, diaportheins A (1) and B (2), were isolated from a culture broth of the fungus Diaporthe sp. BCC 6140. Diaporthein B (2) strongly inhibited the growth of Mycobacterium tuberculosis with the MIC value of 3.1 mug/mL, while diaporthein A (1) showed only mild activity (MIC value of 200 mug/mL). (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：1253 / 1255

页数：3

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