Gene structure and function of the 2′-5′-oligoadenylate synthetase family

被引:194
作者
Justesen, J [1 ]
Hartmann, R [1 ]
Kjeldgaard, NO [1 ]
机构
[1] Aarhus Univ, Dept Mol & Struct Biol, DK-8000 Aarhus, Denmark
关键词
oligoadenylate synthetase; OAS; OASL; 2-5A; chromosome; 12; exon structure; OAS genes;
D O I
10.1007/PL00000644
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
2'-5'-Oligoadenylate synthetase was among the first interferon-induced antiviral enzymes to be discovered. This family of enzymes plays an important role in the mechanisms of action of interferon antiviral activity, but is also involved in other cellular processes such as apoptosis and growth control. We have reviewed the function and genomic structure of this class of at least nine proteins. By studying the recently available data in the human genome database and the human Expressed Sequence Tag database, we have been able to build a comprehensive picture of the 2'-5'-oligoadenylate synthetase gene family and its precise location on chromosome 12. Chromosomal localization as well as the intron/exon structure of all four genes has been established and an overview of the splice variant forms of the 2'-5'-oligoadenylate synthetases arising from expression of the four genes is presented. Alignments of the human 2'-5'-oligoadenylate synthetase sequences with non-human 2'-5'-oligoadenylate synthetase sequences suggest that the exon structure and several amino acid sequence motifs have been conserved during evolution.
引用
收藏
页码:1593 / 1612
页数:20
相关论文
共 80 条
[41]   Identification of the reaction products of (2′-5′)oligoadenylate synthetase in the marine sponge [J].
Kuusksalu, A ;
Subbi, J ;
Pehk, T ;
Reintamm, T ;
Müller, WEG ;
Kelve, M .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1998, 257 (02) :420-426
[42]   Interferon regulatory factors:: the next generation [J].
Mamane, Y ;
Heylbroeck, C ;
Génin, P ;
Algarté, M ;
Servant, MJ ;
LePage, C ;
DeLuca, C ;
Kwon, H ;
Lin, RT ;
Hiscott, J .
GENE, 1999, 237 (01) :1-14
[43]  
MARIE I, 1990, J BIOL CHEM, V265, P18601
[44]  
MARIE I, 1992, J BIOL CHEM, V267, P9933
[45]   MOLECULAR-CLONING AND SEQUENCE OF PARTIAL CDNA FOR INTERFERON-INDUCED (2'-5')OLIGO(A) SYNTHETASE MESSENGER-RNA FROM HUMAN-CELLS [J].
MERLIN, G ;
CHEBATH, J ;
BENECH, P ;
METZ, R ;
REVEL, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (16) :4904-4908
[46]  
MINKS MA, 1980, J BIOL CHEM, V255, P6403
[47]  
MINKS MA, 1979, J BIOL CHEM, V254, P180
[48]   A mammalian 2-5A system functions as an antiviral pathway in transgenic plants [J].
Mitra, A ;
Higgins, DW ;
Langenberg, WG ;
Nie, HQ ;
Sengupta, DN ;
Silverman, RH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (13) :6780-6785
[49]   Virus-induced cell death in plants expressing the mammalian 2',5' oligoadenylate system [J].
Ogawa, T ;
Hori, T ;
Ishida, I .
NATURE BIOTECHNOLOGY, 1996, 14 (11) :1566-1569
[50]   Molecular cloning and characterization of two related and interferon-induced 56-kDa and 30-kDa proteins highly similar to 2′-5′ oligoadenylate synthetase [J].
Rebouillat, D ;
Marié, I ;
Hovanessian, AG .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1998, 257 (02) :319-330