MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells

被引:110
作者
LeibundGut-Landmann, S
Waldburger, JM
Sousa, CRE
Acha-Orbea, H
Reith, W [1 ]
机构
[1] Univ Geneva, Sch Med, Dept Pathol & Immunol, CH-1211 Geneva, Switzerland
[2] London Res Inst, Canc Res UK, Immunobiol Lab, London WC2A 3PX, England
[3] Univ Lausanne, Fac Biol & Med, Dept Biochem, CH-1066 Epalinges, Switzerland
关键词
D O I
10.1038/ni1109
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Major histocompatibility complex (MHC) class II-restricted antigen presentation is essential for the function of dendritic cells (DCs). We show here that plasmacytoid DCs (pDCs) differ from all other DC subsets with respect to expression of CIITA, the 'master regulator' of MHC class II genes. The gene encoding CIITA is controlled by three cell type-specific promoters: pI, pIII and pIV. With gene targeting in mice, we demonstrate that pDCs rely strictly on the B cell promoter pIII, whereas macrophages and all other DCs depend on pI. The molecular mechanisms driving MHC class II expression in pDCs are thus akin to those operating in lymphoid rather than myeloid cells.
引用
收藏
页码:899 / 908
页数:10
相关论文
共 61 条
[1]   Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody [J].
Asselin-Paturel, C ;
Brizard, G ;
Pin, JJ ;
Brière, F ;
Trinchieri, G .
JOURNAL OF IMMUNOLOGY, 2003, 171 (12) :6466-6477
[2]   Mouse type IIFN-producing cells are immature APCs with plasmacytoid morphology [J].
Asselin-Paturel, C ;
Boonstra, A ;
Dalod, M ;
Durand, I ;
Yessaad, N ;
Dezutter-Dambuyant, C ;
Vicari, A ;
O'Garra, A ;
Biron, C ;
Brière, F ;
Trinchieri, G .
NATURE IMMUNOLOGY, 2001, 2 (12) :1144-1150
[3]   Immunobiology of dendritic cells [J].
Banchereau, J ;
Briere, F ;
Caux, C ;
Davoust, J ;
Lebecque, S ;
Liu, YT ;
Pulendran, B ;
Palucka, K .
ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :767-+
[4]   Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements [J].
Barnden, MJ ;
Allison, J ;
Heath, WR ;
Carbone, FR .
IMMUNOLOGY AND CELL BIOLOGY, 1998, 76 (01) :34-40
[5]   Origins and functions of B-1 cells with notes on the role of CD5 [J].
Berland, R ;
Wortis, HH .
ANNUAL REVIEW OF IMMUNOLOGY, 2002, 20 :253-300
[6]   Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: Dependency on antigen dose and differential toll-like receptor ligation [J].
Boonstra, A ;
Asselin-Paturel, C ;
Gilliet, M ;
Crain, C ;
Trinchieri, G ;
Liu, YJ ;
O'Garra, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (01) :101-109
[7]   Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice [J].
Branda, CS ;
Dymecki, SM .
DEVELOPMENTAL CELL, 2004, 6 (01) :7-28
[8]   Origin and filiation of human plasmacytoid dendritic cells [J].
Brière, F ;
Bendriss-Vermare, N ;
Delale, T ;
Burg, S ;
Corbet, C ;
Rissoan, MC ;
Chaperot, L ;
Plumas, J ;
Jacob, MC ;
Trinchieri, G ;
Bates, EEM .
HUMAN IMMUNOLOGY, 2002, 63 (12) :1081-1093
[9]   Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent THI polarization [J].
Cella, M ;
Facchetti, F ;
Lanzavecchia, A ;
Colonna, M .
NATURE IMMUNOLOGY, 2000, 1 (04) :305-310
[10]   Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells [J].
Cella, M ;
Engering, A ;
Pinet, V ;
Pieters, J ;
Lanzavecchia, A .
NATURE, 1997, 388 (6644) :782-787