A comparison of proliferative activity and atypical mitoses in cervical condylomas with various HPV types

被引:12
作者
Mittal, K
Demopoulos, RI
Tata, M
机构
[1] NYU Med Ctr, Dept Pathol, New York, NY 10016 USA
[2] Kaplan Canc Ctr, New York, NY USA
[3] Good Samaritan Hosp, Dept Pathol, Suffern, NY USA
关键词
HPV; MIB1; atypical mitoses; mitoses; cervical condylomas;
D O I
10.1097/00004347-199801000-00005
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Cervical condylomas associated with HPV types 6/11 rarely progress to dysplasia; this progression is more commonly seen in cervical condylomas with HPV types 16/18/31/33/35, This investigation was undertaken to determine if more frequent atypical mitotic figures (MFs) and higher proliferative activity are seen in high-risk condylomas. HPV types present in cervical condylomas were determined by in situ hybridization with biotinylated probes. The cases were also stained immunohistochemically for MIB1. The percentage staining of basal, parabasal, and suprabasal cells was determined by counting 100 cells in the most intensely stained areas. MFs and atypical MFs were counted per 10 high-power-fields (HPFs). Condylomas with HPV 6/11 showed higher MIB1 expression in the basal layer than condylomas with HPV 16/18 and 31/33/35 (p = 0.013). Atypical MFs were seen more frequently in condylomas with HPV types 16/18/31/33/35 (p = 0.02). Differences in mitotic activity and in MIB1 expression in parabasal and suprabasal layers did not reach statistical significance. The presence of atypical MFs may make a greater contribution than increased proliferative activity to progression to dysplasia in cervical condylomas.
引用
收藏
页码:24 / 28
页数:5
相关论文
共 21 条
[1]   Human papillomavirus type influences the extent of chromosomal lag during mitosis in cervical intraepithelial neoplasia grade III [J].
Burger, MPM ;
VanLeeuwen, AM ;
Hollema, H ;
Quint, WGV ;
Pieters, WJLM .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 1997, 16 (01) :10-14
[2]  
CARDO CC, 1994, AM J PATHOL, V144, P500
[3]   THE E5 PROTEIN OF HPV-6, BUT NOT HPV-16, ASSOCIATES EFFICIENTLY WITH CELLULAR GROWTH-FACTOR RECEPTORS [J].
CONRAD, M ;
GOLDSTEIN, D ;
ANDRESSON, T ;
SCHLEGEL, R .
VIROLOGY, 1994, 200 (02) :796-800
[4]   DEGRADATION OF P53 CAN BE TARGETED BY HPV E6 SEQUENCES DISTINCT FROM THOSE REQUIRED FOR P53 BINDING AND TRANSACTIVATION [J].
CROOK, T ;
TIDY, JA ;
VOUSDEN, KH .
CELL, 1991, 67 (03) :547-556
[5]   INDUCTION OF PROLIFERATING CELL NUCLEAR ANTIGEN IN DIFFERENTIATED KERATINOCYTES OF HUMAN PAPILLOMAVIRUS-INFECTED LESIONS [J].
DEMETER, LM ;
STOLER, MH ;
BROKER, TR ;
CHOW, LT .
HUMAN PATHOLOGY, 1994, 25 (04) :343-348
[6]   HOMOLOGOUS SEQUENCES IN ADENOVIRUS E1A AND HUMAN PAPILLOMAVIRUS E7 PROTEINS MEDIATE INTERACTION WITH THE SAME SET OF CELLULAR PROTEINS [J].
DYSON, N ;
GUIDA, P ;
MUNGER, K ;
HARLOW, E .
JOURNAL OF VIROLOGY, 1992, 66 (12) :6893-6902
[7]   CORRELATIVE STUDY OF HUMAN PAPILLOMAVIRUS DNA, HISTOPATHOLOGY, AND MORPHOMETRY IN CERVICAL CONDYLOMA AND INTRAEPITHELIAL NEOPLASIA [J].
FU, YS ;
HUANG, I ;
BEAUDENON, S ;
IONESCO, M ;
BARRASSO, R ;
DEBRUX, J ;
ORTH, G .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 1988, 7 (04) :297-307
[8]  
Furuya H, 1996, Nihon Rinsho, V54, P1916
[9]  
HECK D, 1992, P NATL ACAD SCI USA, V89, P4492
[10]   BIOLOGIC CHARACTERISTICS OF SPECIFIC HUMAN PAPILLOMAVIRUS TYPES PREDICTED FROM MORPHOLOGY OF CERVICAL LESIONS [J].
KADISH, AS ;
HAGAN, RJ ;
RITTER, DB ;
GOLDBERG, GL ;
ROMNEY, SL ;
KANETSKY, PA ;
BEISS, BK ;
BURK, RD .
HUMAN PATHOLOGY, 1992, 23 (11) :1262-1269