Protein aggregation: folding aggregates, inclusion bodies and amyloid

被引：1008

作者：

Fink, AL ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

来源：

FOLDING & DESIGN | 1998年 / 3卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S1359-0278(98)00002-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aggregation results in the formation of inclusion bodies, amyloid fibrils and folding aggregates. Substantial data support the hypothesis that partially folded intermediates are key precursors to aggregates, that aggregation involves specific intermolecular interactions and that most aggregates involve beta sheets.

引用

页码：R9 / R23

页数：15

共 158 条

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