Endothelin-1: a multifunctional molecule in cancer

被引：140

作者：

Grant, K ^{[1
]}

Loizidou, M ^{[1
]}

Taylor, I ^{[1
]}

机构：

[1] Royal Free & UCL, Sch Med, Dept Surg, London W1W 7EJ, England

来源：

BRITISH JOURNAL OF CANCER | 2003年 / 88卷 / 02期

关键词：

endothelin-1; cancer; angiogenesis; tumour growth; apoptosis;

D O I：

10.1038/sj.bjc.6700750

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Endothelin-1 is a small vasoconstrictor peptide that was first identified in 1988. Here we review the evidence implicating ET-1 in tumorigenesis. In particular, we concentrate on the role of ET-1 in mitogenesis, apoptosis, angiogenesis, tumour invasion and metastasis, and discuss the potential for endothelin-system modulation as an adjuvant therapeutic strategy.

引用

页码：163 / 166

页数：4

共 39 条

[1]

Alanen K, 2000, HISTOPATHOLOGY, V36, P161

[2]

Ali H, 2000, J CARDIOVASC PHARM, V36, pS69

[3] The Wigner function for general Lie groups and the wavelet transform [J].

Ali, ST ;

Atakishiyev, NM ;

Chumakov, SM ;

Wolf, KB .

ANNALES HENRI POINCARE, 2000, 1 (04) :685-714

[4] Increased endothelin-1 in colorectal cancer and reduction of tumour growth by ETA receptor antagonism [J].

Asham, E ;

Shankar, A ;

Loizidou, M ;

Fredericks, S ;

Miller, K ;

Boulos, PB ;

Burnstock, G ;

Taylor, I .

BRITISH JOURNAL OF CANCER, 2001, 85 (11) :1759-1763

[5]

Bagnato A, 1999, CANCER RES, V59, P720

[6]

Bagnato A, 1995, CLIN CANCER RES, V1, P1059

[7] Endothelins are angiogenic [J].

Bek, EL ;

McMillen, MA .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2000, 36 :S135-S139

[8] Atrasentan, an endothelin-receptor antagonist for refractory adenocarcinomas: Safety and pharmacokinetics [J].

Carducci, MA ;

Nelson, JB ;

Bowling, MK ;

Rogers, T ;

Eisenberger, MA ;

Sinibaldi, V ;

Donehower, R ;

Leahy, TL ;

Carr, RA ;

Isaacson, JD ;

Janus, TJ ;

Andre, A ;

Hosmane, BS ;

Padley, RJ .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (08) :2171-2180

[9] Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption [J].

Chiao, JW ;

Moonga, BS ;

Yang, YM ;

Kancherla, R ;

Mittelman, A ;

Wu-Wong, JR ;

Ahmed, T .

BRITISH JOURNAL OF CANCER, 2000, 83 (03) :360-365

[10] Modulation of human colon tumor-stromal interactions by the endothelin system [J].

Egidy, G ;

Juillerat-Jeanneret, L ;

Jeannin, JF ;

Korth, P ;

Bosman, FT ;

Pinet, F .

AMERICAN JOURNAL OF PATHOLOGY, 2000, 157 (06) :1863-1874

← 1 2 3 4 →