Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1

被引：169

作者：

Vezzoli, Alessandro ^{[1
]}

Bonadies, Nicolas ^{[2
]}

Allen, Mark D. ^{[1
]}

Freund, Stefan M. V. ^{[3
]}

Santiveri, Clara M. ^{[1
]}

Kvinlaug, Brynn T. ^{[2
]}

Huntly, Brian J. P. ^{[2
]}

Goettgens, Berthold ^{[2
]}

Bycroft, Mark ^{[1
]}

机构：

[1] MRC, Ctr Prot Engn, Cambridge, England

[2] Univ Cambridge, Cambridge Inst Med Res, Dept Haematol, Cambridge, England

[3] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2010年 / 17卷 / 05期

基金：

英国医学研究理事会;

关键词：

BINDING MODULES; STEM-CELLS; CHROMATIN; PROTEIN; METHYLATION; FAMILY;

D O I：

10.1038/nsmb.1797

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Trimethylation of Lys36 in histone H3 (H3K36me3) coordinates events associated with the elongation phase of transcription and is also emerging as an important epigenetic regulator of cell growth and differentiation. We have identified the PWWP domain of bromo and plant homeodomain (PHD) finger-containing protein 1 (BRPF1) as a H3K36me3 binding module and have determined the structure of this domain in complex with an H3K36me3-derived peptide.

引用

收藏

页码：617 / 619

页数：3

相关论文

共 20 条

[1] High-resolution profiling of histone methylations in the human genome [J].

Barski, Artern ;

Cuddapah, Suresh ;

Cui, Kairong ;

Roh, Tae-Young ;

Schones, Dustin E. ;

Wang, Zhibin ;

Wei, Gang ;

Chepelev, Iouri ;

Zhao, Keji .

CELL, 2007, 129 (04) :823-837

[2] MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors [J].

Huntly, BJP ;

Shigematsu, H ;

Deguchi, K ;

Lee, BH ;

Mizuno, S ;

Duclos, N ;

Rowan, R ;

Amaral, S ;

Curley, D ;

Williams, IR ;

Akashi, K ;

Gilliland, DG .

CANCER CELL, 2004, 6 (06) :587-596

[3] Differential chromatin marking of introns and expressed exons by H3K36me3 [J].

Kolasinska-Zwierz, Paulina ;

Down, Thomas ;

Latorre, Isabel ;

Liu, Tao ;

Liu, X. Shirley ;

Ahringer, Julie .

NATURE GENETICS, 2009, 41 (03) :376-381

[4] The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity [J].

Laue, Kathrin ;

Daujat, Sylvain ;

Crump, Justin Gage ;

Plaster, Nikki ;

Roehl, Henry H. ;

Kimmel, Charles B. ;

Schneider, Robert ;

Hammerschmidt, Matthias .

DEVELOPMENT, 2008, 135 (11) :1935-1946

[5] A site to remember: H3K36 methylation a mark for histone deacetylation [J].

Lee, Jung-Shin ;

Shilatifard, Ali .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2007, 618 (1-2) :130-134

[6] Combined action of PHD and chromo domains directs the Rpd3S HDAC to transcribed chromatin [J].

Li, Bing ;

Gogol, Madelaine ;

Carey, Mike ;

Lee, Daeyoup ;

Seidel, Chris ;

Workman, Jerry L. .

SCIENCE, 2007, 316 (5827) :1050-1054

[7] The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains [J].

Maurer-Stroh, S ;

Dickens, NJ ;

Hughes-Davies, L ;

Kouzarides, T ;

Eisenhaber, F ;

Ponting, CP .

TRENDS IN BIOCHEMICAL SCIENCES, 2003, 28 (02) :69-74

[8] A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome [J].

Nimura, Keisuke ;

Ura, Kiyoe ;

Shiratori, Hidetaka ;

Ikawa, Masato ;

Okabe, Masaru ;

Schwartz, Robert J. ;

Kaneda, Yasufumi .

NATURE, 2009, 460 (7252) :287-U157

[9] The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds [J].

Qiu, C ;

Sawada, K ;

Zhang, X ;

Cheng, XD .

NATURE STRUCTURAL BIOLOGY, 2002, 9 (03) :217-224

[10] Multivalent engagement of chromatin modifications by linked binding modules [J].

Ruthenburg, Alexander J. ;

Li, Haitao ;

Patel, Dinshaw J. ;

Allis, C. David .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (12) :983-994