Solution-phase parallel synthesis of a benzoxazinone library using complementary molecular reactivity and molecular recognition (CMR/R) purification technology

被引：67

作者：

Parlow, JJ ^{[1
]}

Flynn, DL ^{[1
]}

机构：

[1] Monsanto Co, U2D, Searle Discovery Res, Parallel Med & Combinatorial Chem Unit, St Louis, MO 63167 USA

来源：

TETRAHEDRON | 1998年 / 54卷 / 16期

关键词：

D O I：

10.1016/S0040-4020(98)00132-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A solution-phase synthesis of a benzoxazinone library is described. The five-step synthesis is accomplished using combinations of complementary molecular reactivity and molecular recognition (CMR/R) purification concepts, including reactant-sequestering resins, reagent-sequestering resins, sequestration-enabling-reagents, reaction-quenching resins, as well as the judicious use of polymeric reagents. The multi-step synthesis affords the desired benzoxazinone products in excellent purities and yields. This study demonstrates that multi-step library syntheses can be performed in solution-phase, and that utilization of CMR/R purification strategies as the sole method of purification can lead to products of high purity. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：4013 / 4031

页数：19

共 18 条

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