Pharmacotherapy for hyperactivity in children with autism and other pervasive developmental disorders

被引:62
作者
Aman, MG [1 ]
Langworthy, KS [1 ]
机构
[1] Ohio State Univ, Nisonger Ctr Mental Retardat & Dev Disabil, Columbus, OH 43210 USA
关键词
autism; hyperactivity; PDDNOS; overactivity; pharmacotherapy; inattention;
D O I
10.1023/A:1005559725475
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
We reviewed pharmacological treatments used in children with autism and PDD-NOS who present with hyperactive symptoms. Some 41 studies were identified from the following drug categories: antipsychotics (n = 13), serotonin reuptake inhibitors (n = 3), antianxiety drugs (n = 4), psychostimulants (n = 10), alpha adrenergic agonists (n = 2), opiate blockers (n = 7), and other drugs (n = 2). Empirical evidence for significant reductions in hyperactive symptoms was strongest for the antipsychotics, psychostimulants, and naltrexone. Most studies have focused on the reduction of overactivity, and more emphasis needs to be placed on distractibility and attentional variables. A theoretical model was proposed in which participants' attentional performance may be used to predict clinical response to psychostimulants. More carefully controlled and comprehensive studies of hyperactivity are badly needed in these children.
引用
收藏
页码:451 / 459
页数:9
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