Molecular Optical Imaging with Radioactive Probes

被引:177
作者
Liu, Hongguang [1 ,2 ,5 ]
Ren, Gang [1 ,2 ]
Miao, Zheng [1 ,2 ]
Zhang, Xiaofen [1 ,2 ,5 ]
Tang, Xiaodong [4 ]
Han, Peizhen [5 ]
Gambhir, Sanjiv S. [1 ,2 ,3 ]
Cheng, Zhen [1 ,2 ]
机构
[1] Stanford Univ, Dept Radiol, Mol Imaging Program Stanford, Stanford, CA 94305 USA
[2] Stanford Univ, Bio X Program, Stanford, CA 94305 USA
[3] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA
[4] Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA
[5] Tsinghua Univ, Peking Union Med Coll, Chinese Acad Med Sci, Inst Radiat Med, Tianjin, Peoples R China
来源
PLOS ONE | 2010年 / 5卷 / 03期
关键词
RGD-BOMBESIN HETERODIMER; SMALL-ANIMAL PET; BREAST-CANCER; NUCLEAR-MEDICINE; BREMSSTRAHLUNG; LIGHT; EXPRESSION; SYMPORTER; ELECTRONS; RADIATION;
D O I
10.1371/journal.pone.0009470
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Optical imaging (OI) techniques such as bioluminescence and fluorescence imaging have been widely used to track diseases in a non-invasive manner within living subjects. These techniques generally require bioluminescent and fluorescent probes. Here we demonstrate the feasibility of using radioactive probes for in vivo molecular OI. Methodology/ Principal Findings: By taking the advantages of low energy window of light (1.2-3.1 eV, 400-1000 nm) resulting from radiation, radionuclides that emit charged particles such as b + and b 2 can be successfully imaged with an OI instrument. In vivo optical images can be obtained for several radioactive probes including 2-deoxy-2-[F-18] fluoro-D-glucose ([F-18] FDG), Na F-18, (NaI)-I-131, (YCI3)-Y-90 and a Y-90 labeled peptide that specifically target tumors. Conclusions/Significance: These studies demonstrate generalizability of radioactive OI technique. It provides a new molecular imaging strategy and will likely have significant impact on both small animal and clinical imaging.
引用
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页数:9
相关论文
共 27 条
[21]   Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared flurophore: Feasibility study [J].
Sevick-Muraca, Eva M. ;
Sharma, Ruchi ;
Rasmussen, John C. ;
Marshall, Milton V. ;
Wendt, Juliet A. ;
Pham, Hoang Q. ;
Bonefas, Elizabeth ;
Houston, Jessica P. ;
Sampath, Lakshmi ;
Adams, Kristen E. ;
Blanchard, Darlene Kay ;
Fisher, Ronald E. ;
Chiang, Stephen B. ;
Elledge, Richard ;
Mawad, Michel E. .
RADIOLOGY, 2008, 246 (03) :734-741
[22]  
SHEN S, 1994, J NUCL MED, V35, P1381
[23]  
Siegel JA, 1996, J NUCL MED, V37, P495
[24]   Peptide-receptor radionuclide therapy for endocrine tumors [J].
van Essen, Martijn ;
Krenning, Eric P. ;
Kam, Boen L. R. ;
de Jong, Marion ;
Valkema, Roelf ;
Kwekkeboom, Dik J. .
NATURE REVIEWS ENDOCRINOLOGY, 2009, 5 (07) :382-393
[25]   Molecular imaging in cancer [J].
Weissleder, R .
SCIENCE, 2006, 312 (5777) :1168-1171
[26]   Scaling down imaging: Molecular mapping of cancer in mice [J].
Weissleder, R .
NATURE REVIEWS CANCER, 2002, 2 (01) :11-18
[27]   Shedding light onto live molecular targets [J].
Weissleder, Ralph ;
Ntziachristos, Vasilis .
NATURE MEDICINE, 2003, 9 (01) :123-128