A Convenient Synthesis of Benzonitriles via Electrophilic Cyanation with N-Cyanobenzimidazole

被引：92

作者：

Anbarasan, Pazhamalai ^{[1
]}

Neumann, Helfried ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse EV, D-18059 Rostock, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 16期

关键词：

arenes; benzimidazole; cyanides; electrophilic cyanation; Grignard reaction; PALLADIUM-CATALYZED CYANATION; ARYL HALIDES; EFFICIENT SYNTHESIS; GRIGNARD-REAGENTS; POTASSIUM HEXACYANOFERRATE(II); ALKYL-HALIDES; SYSTEM; BROMIDES; IRON; 1-CYANOBENZOTRIAZOLE;

D O I：

10.1002/chem.201000086

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Couplings: N-Cyanobenzimidazole has been used in the synthesis of aryl- and heteroarylnitriles from the corresponding Grignard reagents (see scheme). This electrophilic cyanation is further extended to the synthesis of 2-cyano1,1'-biaryls through a domino Grignard-coupling/ cyanation strategy. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4725 / 4728

页数：4

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