Self-Digestion for Lifespan Extension: Enhanced Autophagy Delays Aging

被引：14

作者：

Arensman, Michael D. ^{[1
]}

Eng, Christina H. ^{[1
]}

机构：

[1] Pfizer, Oncol Res & Dev, Pearl River, NY 10965 USA

来源：

MOLECULAR CELL | 2018年 / 71卷 / 04期

关键词：

TUMORIGENESIS; BECLIN-1; GENE;

D O I：

10.1016/j.molcel.2018.08.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

By systemically boosting autophagy with a knockin mutation that prevents binding of beclin 1 to BCL2, Fernandez et al. (2018) demonstrate that enhanced autophagy prolongs lifespan in mammals.

引用

页码：485 / 486

页数：2

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