Detection of the high-level aminoglycoside resistance gene aph(2")-Ib in Enterococcus faecium

被引：90

作者：

Kao, SJ

You, L

Clewell, DB

Donabedian, SM

Zervos, MJ

Petrin, J

Shaw, KJ

Chow, JW

机构：

[1] John D Dingell VA Med Ctr, Res & Med Serv, Detroit, MI 48201 USA

[2] Wayne State Univ, Sch Med, Detroit, MI 48201 USA

[3] Univ Michigan, Dept Biol, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Mat Sci, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA

[6] William Beaumont Hosp, Royal Oak, MI 48073 USA

[7] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 10期

关键词：

D O I：

10.1128/AAC.44.10.2876-2879.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A new high-level gentamicin resistance gene, designated aph(2")-Ib, was cloned from Enterococcus faecium SF11770. The deduced amino acid sequence of the 897-bp open reading frame of aph(2")-Ib shares homology with the aminoglycoside-modifying enzymes AAC(6')APH(2"), APH(2")-Ic, and APH(2")-Id. The observed phosphotransferase activity is designated APH(2")-Ib.

引用

页码：2876 / 2879

页数：4