A new reassortment of influenza A (H7N9) virus causing human infection in Beijing, 2014

被引：12

作者：

Bi, Yuhai ^{[1
,2
,3
]}

Liu, Jingyuan ^{[4
]}

Xiong, Haofeng ^{[4
]}

Zhang, Yue ^{[5
,6
]}

Liu, Di ^{[2
,3
,7
]}

Liu, Yingxia ^{[1
]}

Gao, George F. ^{[1
,2
,3
]}

Wang, Beibei ^{[5
,6
]}

机构：

[1] Shenzhen Third Peoples Hosp, Shenzhen Key Lab Pathogen & Immun, Shenzhen 518112, Peoples R China

[2] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol CASPMI, Beijing 100101, Peoples R China

[3] Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, Beijing 100101, Peoples R China

[4] Capital Med Univ, Beijing Ditan Hosp, Intens Care Unit, Beijing 100015, Peoples R China

[5] Capital Med Univ, Beijing Ditan Hosp, Inst Infect Dis, Beijing 100015, Peoples R China

[6] Beijing Key Lab Emerging Infect Dis, Beijing 100015, Peoples R China

[7] Chinese Acad Sci, Network Informat Ctr, Inst Microbiol, Beijing 100101, Peoples R China

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

中国国家自然科学基金;

关键词：

A(H7N9) VIRUS; CYTOKINE; HYPERCYTOKINEMIA; PATHOGENICITY; DYSFUNCTION; INDUCTION; SEVERITY; IMMUNITY; ALPHA; CHINA;

D O I：

10.1038/srep26624

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A 73-year-old man was confirmed to have an influenza A (H7N9) virus infection, and the causative agent A/Beijing/02/2014(H7N9) virus was isolated. Genetic and phylogenetic analyses revealed that the virus belonged to a novel genotype, which probably emerged and further reassorted with other H9 or H7 viruses in poultry before transmitting to humans. This virus caused a severe infection with high levels of cytokines and neutralizing antibodies. Eventually, the patient was cured after serially combined treatments. Taken together, our findings indicated that this novel genotype of the human H7N9 virus did not evolve directly from the first Beijing isolate A/Beijing/01/2013(H7N9), suggesting that the H7N9 virus has not obtained the ability for human-to-human transmissibility and the virus only evolves in poultry and then infects human by direct contact. Hence, the major measures to prevent human H7N9 virus infection are still to control and standardize the live poultry trade. Early antiviral treatment with combination therapies, including mechanical ventilation, nutrition support and symptomatic treatment, are effective for H7N9 infection.

引用

页数：8

共 40 条

[1] Assessment of the Internal Genes of Influenza A (H7N9) Virus Contributing to High Pathogenicity in Mice [J].

Bi, Yuhai ;

Xie, Qing ;

Zhang, Shuang ;

Li, Yun ;

Xiao, Haixia ;

Jin, Tao ;

Zheng, Weinan ;

Li, Jing ;

Jia, Xiaojuan ;

Sun, Lei ;

Liu, Jinhua ;

Qin, Chuan ;

Gao, George F. ;

Liu, Wenjun .

JOURNAL OF VIROLOGY, 2015, 89 (01) :2-13

[2] Human infection with avian influenza A(H7N9) virus re-emerges in China in winter 2013 [J].

Chen, E. ;

Chen, Y. ;

Fu, L. ;

Chen, Z. ;

Gong, Z. ;

Mao, H. ;

Wang, D. ;

Ni, M. Y. ;

Wu, P. ;

Yu, Z. ;

He, T. ;

Li, Z. ;

Gao, J. ;

Liu, S. ;

Shu, Y. ;

Cowling, B. J. ;

Xia, S. ;

Yu, H. .

EUROSURVEILLANCE, 2013, 18 (43) :2-11

[3] Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome [J].

Chen, Yu ;

Liang, Weifeng ;

Yang, Shigui ;

Wu, Nanping ;

Gao, Hainv ;

Sheng, Jifang ;

Yao, Hangping ;

Wo, Jianer ;

Fang, Qiang ;

Cui, Dawei ;

Li, Yongcheng ;

Yao, Xing ;

Zhang, Yuntao ;

Wu, Haibo ;

Zheng, Shufa ;

Diao, Hongyan ;

Xia, Shichang ;

Zhang, Yanjun ;

Chan, Kwok-Hung ;

Tsoi, Hoi-Wah ;

Teng, Jade Lee-Lee ;

Song, Wenjun ;

Wang, Pui ;

Lau, Siu-Ying ;

Zheng, Min ;

Chan, Jasper Fuk-Woo ;

To, Kelvin Kai-Wang ;

Chen, Honglin ;

Li, Lanjuan ;

Yuen, Kwok-Yung .

LANCET, 2013, 381 (9881) :1916-1925

[4] Cytokine and Chemokine Levels in Patients Infected With the Novel Avian Influenza A (H7N9) Virus in China [J].

Chi, Ying ;

Zhu, Yefei ;

Wen, Tian ;

Cui, Lunbiao ;

Ge, Yiyue ;

Jiao, Yongjun ;

Wu, Tao ;

Ge, Aihua ;

Ji, Hong ;

Xu, Ke ;

Bao, Changjun ;

Zhu, Zheng ;

Qi, Xian ;

Wu, Bin ;

Shi, Zhiyang ;

Tang, Fenyang ;

Xing, Zheng ;

Zhou, Minghao .

JOURNAL OF INFECTIOUS DISEASES, 2013, 208 (12) :1962-1967

[5] A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence [J].

Conenello, Gina M. ;

Zamarin, Dmitriy ;

Perrone, Lucy A. ;

Tumpey, Terrence ;

Palese, Peter .

PLOS PATHOGENS, 2007, 3 (10) :1414-1421

[6] Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus [J].

Cui, Lunbiao ;

Liu, Di ;

Shi, Weifeng ;

Pan, Jingcao ;

Qi, Xian ;

Li, Xianbin ;

Guo, Xiling ;

Zhou, Minghao ;

Li, Wei ;

Li, Jun ;

Haywood, Joel ;

Xiao, Haixia ;

Yu, Xinfen ;

Pu, Xiaoying ;

Wu, Ying ;

Yu, Huiyan ;

Zhao, Kangchen ;

Zhu, Yefei ;

Wu, Bin ;

Jin, Tao ;

Shi, Zhiyang ;

Tang, Fenyang ;

Zhu, Fengcai ;

Sun, Qinglan ;

Wu, Linhuan ;

Yang, Ruifu ;

Yan, Jinghua ;

Lei, Fumin ;

Zhu, Baoli ;

Liu, Wenjun ;

Ma, Juncai ;

Wang, Hua ;

Gao, George F. .

NATURE COMMUNICATIONS, 2014, 5

[7]

de Jong M. D., NAT MED

[8] Detection of mild to moderate influenza A/H7N9 infection by China's national sentinel surveillance system for influenza-like illness: case series [J].

Dennis, K. M. ;

Liao, Qiaohong ;

Wu, Peng ;

Gao, Zhancheng ;

Cao, Bin ;

Feng, Luzhao ;

Xu, Xiaoling ;

Jiang, Hui ;

Li, Ming ;

Bao, Jing ;

Zheng, Jiandong ;

Zhang, Qian ;

Chang, Zhaorui ;

Li, Yu ;

Yu, Jianxing ;

Liu, Fengfeng ;

Ni, Michael Y. ;

Wu, Joseph T. ;

Cowling, Benjamin J. ;

Yang, Weizhong ;

Leung, Gabriel M. ;

Yu, Hongjie .

BMJ-BRITISH MEDICAL JOURNAL, 2013, 346

[9] Mapping Spread and Risk of Avian Influenza A (H7N9) in China [J].

Fang, Li-Qun ;

Li, Xin-Lou ;

Liu, Kun ;

Li, Yin-Jun ;

Yao, Hong-Wu ;

Liang, Song ;

Yang, Yang ;

Feng, Zi-Jian ;

Gray, Gregory C. ;

Cao, Wu-Chun .

SCIENTIFIC REPORTS, 2013, 3

[10] Immunoparalysis and adverse outcomes from critical illness [J].

Frazier, W. Joshua ;

Hall, Mark W. .

PEDIATRIC CLINICS OF NORTH AMERICA, 2008, 55 (03) :647-+

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