Alteration in expression of p27 in auditory epithelia and neurons of mice during degeneration

被引：11

作者：

Endo, T

Nakagawa, T ^{[1
]}

Lee, JE

Dong, YY

Kim, TS

Iguchi, F

Taniguchi, Z

Naito, T

Ito, J

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kyoto 6068507, Japan

[2] Kyungpook Natl Univ Hosp, Sch Med, Dept Otolaryngol, Taegu, South Korea

来源：

NEUROSCIENCE LETTERS | 2002年 / 334卷 / 03期

关键词：

p27; cyclin-dependent kinase inhibitor; inner ear; cell death; cochlea; spiral ganglion neuron;

D O I：

10.1016/S0304-3940(02)01115-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of this study was to examine roles of p27, a cyclin-dependent kinase inhibitor, in cochleae of adult mice. Expression of p27 was found in cochlear supporting cells and spiral ganglion neurons of normal mice. Cisplatin treatment caused progressive degeneration of cochlear supporting cells and spiral ganglion neurons, and numbers of p27-positive cells in these cells decreased. This indicates a close relationship between p27 and cell death in cochleae. However, the relationships between decrease in number of p27-positive cells and that of survival cells differed according to type of cell. For Deiters' cells, there was apparent decrease in number of p27-positive cells, although no decrease in cell numbers. The present findings indicate that p27 plays roles in degeneration of cochleae according to cell type. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：173 / 176

页数：4

共 12 条

[1]

Chen P, 1999, DEVELOPMENT, V126, P1581

[2] Transforming growth factor-α-induced cellular changes in organotypic cultures of juvenile, amikacin-treated rat organ of Corti [J].