Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala

被引：135

作者：

Doyere, Valerie

Debiec, Jacek

Monfils, Marie-H

Schafe, Glenn E.

LeDoux, Joseph E.

机构：

[1] NYU, Ctr Neural Sci, WM Keck Fdn Lab Neurobiol, New York, NY 10003 USA

[2] Univ Paris 11, CNRS, UMR8620, NAMC, F-91405 Orsay, France

[3] Yale Univ, Dept Psychol, New Haven, CT 06520 USA

来源：

NATURE NEUROSCIENCE | 2007年 / 10卷 / 04期

关键词：

D O I：

10.1038/nn1871

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

When reactivated, memories enter a labile, protein synthesis dependent state, a process referred to as reconsolidation. Here, we show in rats that fear memory retrieval produces a synaptic potentiation in the lateral amygdala that is selective to the reactivated memory, and that disruption of reconsolidation is correlated with a reduction of synaptic potentiation in the lateral amygdala. Thus, both retrieval and reconsolidation alter memories via synaptic plasticity at selectively targeted synapses.

引用

收藏

页码：414 / 416

页数：3

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