Bradycardia leading to asystole during dexmedetomidine infusion in an 18 year-old double-lung transplant recipient

被引：63

作者：

Zhang, Xiaopeng ^{[1
]}

Schmidt, Ulrich ^{[2
]}

Wain, John C. ^{[3
]}

Bigatello, Luca ^{[4
]}

机构：

[1] Geisinger Med Ctr, Div Anesthesiol, Danville, PA 17821 USA

[2] Harvard Univ, Massachusetts Gen Hosp, Dept Anesthesia & Crit Care, Sch Med, Boston, MA 02114 USA

[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Thorac Surg, Boston, MA 02114 USA

[4] VA Boston Healthcare Syst, Anesthesia & Crit Care Serv, Boston, MA 02132 USA

来源：

JOURNAL OF CLINICAL ANESTHESIA | 2010年 / 22卷 / 01期

关键词：

Asystole; Bradycardia; Dexmedetomidine infusion; Double lung transplantation; INTENSIVE-CARE-UNIT; CARDIAC-ARREST; PROPOFOL; SEDATION; SURGERY; PHARMACOKINETICS; PHARMACODYNAMICS; VOLUNTEERS; FENTANYL; AGENT;

D O I：

10.1016/j.jclinane.2009.06.002

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

The case of an 18 year-old double-lung transplant recipient recovering from acute respiratory distress syndrome who developed repeated episodes of bradycardia and asystole (maximum duration: 10 sec) during dexmedetomidine administration is presented. Increased baseline vagal tone, paroxysmal coughing spells, and opioid administration were likely contributors to the episodes. Discontinuation of the drug restored regular sinus rhythm. Double-lung transplant recipients may be at especially increased risk for this phenomenon as a result of changes in the autonomic innervation of the heart. Published by Elsevier Inc.

引用

页码：45 / 49

页数：5

共 26 条

[1]

The effects of pre-operative dexmedetomidine infusion on hemodynamics in patients with pulmonary hypertension undergoing mitral valve replacement surgery [J].

But, A. K. ;

Ozgul, U. ;

Erdil, F. ;

Gulhas, N. ;

Toprak, H. I. ;

Durmus, M. ;

Ersoy, M. O. .

ACTA ANAESTHESIOLOGICA SCANDINAVICA, 2006, 50 (10) :1207-1212

[2]

Comparing dexmedetomidine prescribing patterns and safety in the naturalistic setting versus published data [J].

Dasta, JF ;

Kane-Gill, SL ;

Durtschi, AJ .

ANNALS OF PHARMACOTHERAPY, 2004, 38 (7-8) :1130-1135

[3]

The pharmacokinetics of dexmedetomidine in volunteers with severe renal impairment [J].

De Wolf, AM ;

Fragen, RJ ;

Avram, MJ ;

Fitzgerald, PC ;

Rahimi-Danesh, F .

ANESTHESIA AND ANALGESIA, 2001, 93 (05) :1205-1209

[4]

The effects of increasing plasma concentrations of dexmedetomidine in humans [J].

Ebert, TJ ;

Hall, JE ;

Barney, JA ;

Uhrich, TD ;

Colinco, MD .

ANESTHESIOLOGY, 2000, 93 (02) :382-394

[5]

Flacke W E, 1992, J Cardiothorac Vasc Anesth, V6, P418, DOI 10.1016/1053-0770(92)90006-S

[6]

Dexmedetomidine: An updated review [J].

Gerlach, Anthony T. ;

Dasta, Joseph F. .

ANNALS OF PHARMACOTHERAPY, 2007, 41 (02) :245-254

[7]

ICU sedation after coronary artery bypass graft surgery: Dexmedetomidine-based versus propofol-based sedation regimens [J].

Herr, DL ;

Sum-Ping, STJ ;

England, M .

JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 2003, 17 (05) :576-584

[8]

EFFECTS OF DEXMEDETOMIDINE ON CONTRACTILITY, RELAXATION, AND INTRACELLULAR CALCIUM TRANSIENTS OF ISOLATED VENTRICULAR MYOCARDIUM [J].

HOUSMANS, PR .

ANESTHESIOLOGY, 1990, 73 (05) :919-922

[9]

Dexmedetomidine pharmacodynamics: Part I - Crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers [J].

Hsu, YW ;

Cortinez, LI ;

Robertson, KM ;

Keifer, JC ;

Sum-Ping, ST ;

Moretti, EW ;

Young, CC ;

Wright, DR ;

MacLeod, DB ;

Somma, J .

ANESTHESIOLOGY, 2004, 101 (05) :1066-1076

[10]

Dexmedetomidine and cardiac arrest [J].

Ingersoll-Weng, E ;

Manecke, GP ;

Thistlethwaite, PA .

ANESTHESIOLOGY, 2004, 100 (03) :738-739

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