A synthetic transmembrane polyether model active in lipid bilayers

被引：15

作者：

Espínola, CG ^{[1
]}

Pérez, R ^{[1
]}

Martín, JD ^{[1
]}

机构：

[1] CSIC, Inst Invest Quim, Seville 41092, Spain

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 20期

关键词：

D O I：

10.1021/ol0063555

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A model polyether-based ion channel like compound was rationally designed and synthesized. Macromolecules 1c-f were incorporated into phospholipid vesicles and shown to facilitate the transmembrane sodium transport.

引用

页码：3161 / 3164

页数：4

共 40 条

[1] Unusually long open times, determined by planar bilayer conductances studies, for a synthetic tris(macrocycle) that functions as a transmembrane channel in a phospholipid bilayer [J].

Abel, E ;

Meadows, ES ;

Suzuki, I ;

Jin, T ;

Gokel, GW .

CHEMICAL COMMUNICATIONS, 1997, (12) :1145-1146

[2] VESICLE FORMATION FROM N-ALKYLINDOLES - IMPLICATIONS FOR TRYPTOPHAN WATER INTERACTIONS [J].

ABEL, E ;

FEDDERS, MF ;

GOKEL, GW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (04) :1265-1270

[3] SYNTHETIC PEPTIDES AS MODELS FOR ION CHANNEL PROTEINS [J].

AKERFELDT, KS ;

LEAR, JD ;

WASSERMAN, ZR ;

CHUNG, LA ;

DEGRADO, WF .

ACCOUNTS OF CHEMICAL RESEARCH, 1993, 26 (04) :191-197

[4] An olefin metathesis approach to 36- and 72-membered archaeal macrocyclic membrane lipids [J].

Arakawa, K ;

Eguchi, T ;

Kakinuma, K .

JOURNAL OF ORGANIC CHEMISTRY, 1998, 63 (14) :4741-4745

[5] NA-23-NUCLEAR MAGNETIC-RESONANCE INVESTIGATION OF GRAMICIDIN-INDUCED ION-TRANSPORT THROUGH MEMBRANES UNDER EQUILIBRIUM CONDITIONS [J].

BUSTER, DC ;

HINTON, JF ;

MILLETT, FS ;

SHUNGU, DC .

BIOPHYSICAL JOURNAL, 1988, 53 (02) :145-152

[6] Self-assembly through stepwise crystallization [J].

Chen, YY ;

Baker, GL ;

Ding, YQ ;

Rabolt, JF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (29) :6962-6963

[7] The structure of the potassium channel:: Molecular basis of K+ conduction and selectivity [J].

Doyle, DA ;

Cabral, JM ;

Pfuetzner, RA ;

Kuo, AL ;

Gulbis, JM ;

Cohen, SL ;

Chait, BT ;

MacKinnon, R .

SCIENCE, 1998, 280 (5360) :69-77

[8] A voltage-gated ion channel based on a bis-macrocyclic bolaamphiphile [J].

Fyles, TM ;

Loock, D ;

Zhou, X .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (13) :2997-3003

[9]

FYLES TM, 1996, COMPREHENSIVE SUPRAM, V10, P53

[10] Synthesis of asymmetric septi-(p-phenylene)s [J].

Ghebremariam, B ;

Matile, S .

TETRAHEDRON LETTERS, 1998, 39 (30) :5335-5338

← 1 2 3 4 →